Keratinocyte PIEZO1 modulates cutaneous mechanosensation
- Medical College of Wisconsin, United States
Abstract
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice.
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All data generated or analyzed during this study are included in the manuscript and supporting files.
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Funding
National Institute of Neurological Disorders and Stroke (NS040538)
- Cheryl L Stucky
National Institute of Neurological Disorders and Stroke (NS070711)
- Cheryl L Stucky
National Institute of Neurological Disorders and Stroke (NS108278)
- Cheryl L Stucky
Medical College of Wisconsin (Advancing a Healthier Wisconsin Endowment)
- Cheryl L Stucky
National Institute of Neurological Disorders and Stroke (1F31NS125941-01)
- Alexander R Mikesell
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: Animal experimentation: All protocols were in accordance with National Institutes of Health guidelines and were approved by the Institutional Animal Care and Use Committee at the Medical College of Wisconsin (Milwaukee, WI; protocol #383).
Copyright
© 2022, Mikesell et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Keratinocyte PIEZO1 modulates cutaneous mechanosensation
eLife 11:e65987.
https://doi.org/10.7554/eLife.65987
