Developmental changes in story-evoked responses in the neocortex and hippocampus
Abstract
How does the representation of naturalistic life events change with age? Here we analyzed fMRI data from 414 children and adolescents (5 - 19 years) as they watched a narrative movie. In addition to changes in the degree of inter-subject correlation (ISC) with age in sensory and medial parietal regions, we used a novel measure (between-group ISC) to reveal age-related shifts in the responses across the majority of the neocortex. Over the course of development, brain responses became more discretized into stable and coherent events and shifted earlier in time to anticipate upcoming perceived event transitions, measured behaviorally in an age-matched sample. However, hippocampal responses to event boundaries actually decreased with age, suggesting a shifting division of labor between episodic encoding processes and schematic event representations between the ages of 5 and 19.
Data availability
All neuroimaging data is available at: http://fcon_1000.projects.nitrc.org/indi/cmi_healthy_brain_network/sharing_neuro.html, and all behavioral data is available at: https://github.com/samsydco/HBN
Article and author information
Author details
Funding
Andrew Africk
- Samantha S Cohen
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Reviewing Editor
- Peter Kok, University College London, United Kingdom
Ethics
Human subjects: Informed consent, and consent to publish, was obtained from all subjects 18 years and older. Consent was obtained from the parents or legal guardians for participants younger than 18 years. The neuroimaging portion of the study was approved by the Chesapeake Institutional Review Board (https://www.chesapeakeirb.com/). The behavioral experimental procedures were approved by the Columbia University IRB (protocol number AAAS0252, for adult data, and AAAT8550, for child data).
Version history
- Preprint posted: April 12, 2021 (view preprint)
- Received: April 15, 2021
- Accepted: June 17, 2022
- Accepted Manuscript published: July 5, 2022 (version 1)
- Version of Record published: July 27, 2022 (version 2)
Copyright
© 2022, Cohen et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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