1. Computational and Systems Biology
  2. Medicine
Download icon

Heart Attack: Working together

  1. Regan Odongo
  2. Tunahan Çakır  Is a corresponding author
  1. Gebze Technical University, Turkey
Insight
Cite this article as: eLife 2021;10:e69863 doi: 10.7554/eLife.69863
1 figure

Figures

Heart attacks cause molecular changes in multiple tissues.

Acute heart attacks were induced in mice by blocking some of the arteries that supply blood to the heart, resulting in an irregular heartbeat. Samples were then collected from the heart, skeletal muscle, liver and adipose, or 'fat', tissues of these mice (red heart) and control animals that had not undergone a heart attack (green heart). RNA sequencing revealed that the heart attack altered genes expressed in all four of these tissues. Further computational simulations suggest that these genetic changes alter the production of metabolites that are then taken up by the other tissues (represented by arrows).

Image credit: Regan Odongo.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)