Cortico-subcortical β burst dynamics underlying movement cancellation in humans
- Department of Psychological and Brain Sciences, University of Iowa, United States
- Department of Neurosurgery, University of Iowa Carver College of Medicine, United States
- Iowa Neuroscience Institute, University of Iowa, United States
- Department of Neurology, University of Iowa Carver College of Medicine, United States
Figures
Figure 1 with 1 supplement
Averaged β power and β burst rates decreased across recording sites during movement execution.
(A) Broadband ERSPs shown were computed from 100ms preceding to 1500ms following the go signal. The two left-most plots include ERSPs from the localizer block and the right-most plots include ERSPs …
Figure 1—figure supplement 1
Averaged ERSPs from all SMC contact pairs, 1000 ms before to 1000 ms following movement execution during contralateral correct go trials.
The data was baseline-corrected using a baseline window from 1100 ms before to 1000 ms before response. Electrodes selected for the β burst analysis are shown in the central column, flanked by …
Figure 2
Results from a lagged coherence analysis on epoched data including go and stop trials.
(A) While coherence is relatively high at one cycle (current phase predicts phase in one cycle well), lagged coherence decreases over time so that lagged coherence in the β band is relatively low at …
Figure 3 with 4 supplements
β burst rates increase following stop signals.
(A) Increases in average β band activity are observed at all subcortical recording sites during stop trials (contrast shown is between successful stops and correct go trials). (B) The total number …
Figure 3—figure supplement 1
Participants performed an auditory version of the stop-signal task while LFP recordings were collected.
Figure 3—figure supplement 2
β burst rates increase following stop signals in ventral and dorsal STN.
Burst rates increased at early latencies in both dorsal and ventral STN (when quantified between SSD and SSRT) and at later latencies following SSRT. These differences could not be accounted for by …
Figure 3—figure supplement 3
Comparing β burst counts and rates across hemispheres.
(A) The total number of β bursts was quantified between trial-wise stop-signal onset (SSD) and participant-wise SSRT. For matched go-trials, this window began at current SSD stored in the staircase. …
Figure 3—figure supplement 4
Exemplar estimations of recording lead locations based on pre- and post-operative imaging and planned implant trajectory in a VIM and STN DBS case.
VIM (A) and STN (C – sagittal view, D – coronal view) implants were placed using framed indirect stereotactic targeting refined by standard confirmatory physiologic testing and macrostimulation. STN …
Figure 4 with 1 supplement
β burst rates in SMC increase following STN bursts.
The left column of plots displays the timing of SMC bursts with respect to subcortical bursts, in 50ms time bins. The right column displays timing of subcortical bursts with respect to SMC bursts. …
Figure 4—figure supplement 1
β burst rates in SMC preceding and following bursts in ventral and dorsal STN.
When STN electrodes are chosen based on location (contacts 0/1 = ventral, contacts 2/3 = dorsal) instead of number of β bursts over the recording, no significant temporally resolved relationships …
Figure 5
β bursts in STN precede bursts in thalamus.
A) The timing of first bursts from the STN in STN DBS patients and thalamic regions in thalamus DBS patients are shown with respect to the stop-signal (left) and participant-wise SSRT (right). First …
Author response image 1
Main effect of trial type (go + fail): F = 35.78, p <.0001; no main effect of burst presence: F = 0.13, p = .72; no interaction effect: F = 0.88, p = .36.
Tables
Table 1
Means of stop-signal task behavioral performance metrics.
* Indicates significant difference between thalamic and STN groups at p < 0.0001. SD = standard deviation.
| Reaction times (ms) | Accuracy | |||
|---|---|---|---|---|
| Go | Failed stop | SSRT | Go trials* | Stop trials |
| All participants | ||||
| 943 (SD: 213) | 763 (SD: 174) | 474 (SD: 232) | 0.89 (SD: 0.07) | 0.61 (SD: 0.16) |
| STN DBS | ||||
| 952 (SD: 234) | 786 (SD: 213) | 533 (SD: 296) | 0.83 (SD: 0.05) | 0.55 (SD: 0.18) |
| Thalamic DBS | ||||
| 934 (SD: 203) | 741 (SD: 136) | 421 (SD: 150) | 0.94 (SD: 0.04) | 0.65 (SD: 0.11) |
Additional files
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Transparent reporting form
- https://cdn.elifesciences.org/articles/70270/elife-70270-transrepform1-v2.pdf
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Supplementary file 1
Information about participant diagnoses, handedness, symptom laterality, and pre-operative symptom severity scores.
For participants with Parkinson’s disease, scores shown are from the motor examination portion (i.e., total part III) of the Unified Parkinson’s disease rating scale (UPDRS). For essential tremor participants, scores are from the Fahn-Tolosa tremor scale. All Parkinson’s disease patients besides participant 2 were diagnosed with idiopathic Parkinson’s disease. Participant 2 had a diagnosis of both idiopathic Parkinson’s and essential tremor.
- https://cdn.elifesciences.org/articles/70270/elife-70270-supp1-v2.docx
