Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals

  1. Rodrigo M Young  Is a corresponding author
  2. Camila J Solis
  3. Andres Barriga-Fehrman
  4. Carlos Abogabir
  5. Alvaro R Thadani
  6. Mariana Labarca
  7. Eva Bustamante
  8. Cecilia V Tapia
  9. Antonia G Sarda
  10. Francisca Sepulveda
  11. Nadia Pozas
  12. Leslie C Cerpa
  13. María A Lavanderos
  14. Nelson M Varela
  15. Alvaro Santibañez
  16. Ana M Sandino
  17. Felipe Reyes-Lopez
  18. Garth Dixon
  19. Luis A Quiñones  Is a corresponding author
  1. Diagnosis Biotech, Chile
  2. Institute of Ophthalmology, University College London, United Kingdom
  3. Grupo Oncológico Cooperativo Chileno de Investigación, Chile
  4. Laboratorio de Especialidad, Clínica Dávila, Chile
  5. Laboratory of Chemical Carcinogenesis and Pharmacogenetics (Chilean Health Council Diagnostic Covid19 Laboratory), Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Chile
  6. Centro de Biotecnología Acuícola, Facultad de Química y Biología, Chile
  7. Programa Disciplinario de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Chile
  8. Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Chile
  9. Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Spain
  10. Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Chile
  11. Department of Microbiology, Virology and Infection Control, Hospital National Health Service Foundation Trust, United Kingdom
  12. National Institute for Health Research Biomedical Research Centre at Great Ormond Hospital for Children National Health Service Foundation Trust and University College, United Kingdom
1 figure and 4 additional files

Figures

Figure 1 with 2 supplements
Phone Screen Testing and RT-PCR can identify individuals with high SARS-CoV-2 viral load.

(A) Schematic of smartphone sampling. Swabbing follows the dashed line indicated trajectory. (B, D) Histograms showing the distribution of individuals on ranges of clinical RT-PCR Ct value results …

Figure 1—figure supplement 1
Pilot and validation study cohort data analysis.

(A, B) Two-by-two tables for sensitivity and specificity of PoST method compared to nasopharyngeal RT-PCR results in the (A) pilot cohort (Source data 1) and (B) validation cohort (Source data 2). (C…

Figure 1—figure supplement 2
SARS-CoV2-19 RT-PCR cycle threshold (Ct) values in Chilean individuals.

(A–H) Histograms representing the Ct value distribution of the patients from Dávila Clinic (Santiago, Chile) between March and October 2020 (n = 7569, Source data 3).

Additional files

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