Abstract

The sharing of research data is essential to ensure reproducibility and maximize the impact of public investments in scientific research. Here we describe OpenNeuro, a BRAIN Initiative data archive that provides the ability to openly share data from a broad range of brain imaging data types following the FAIR principles for data sharing. We highlight the importance of the Brain Imaging Data Structure (BIDS) standard for enabling effective curation, sharing, and reuse of data. The archive presently shares more than 600 datasets including data from more than 20,000 participants, comprising multiple species and measurement modalities and a broad range of phenotypes. The impact of the shared data is evident in a growing number of published reuses, currently totalling more than 150 publications. We conclude by describing plans for future development and integration with other ongoing open science efforts.

Data availability

The OpenNeuro data repository is accessible at http://openneuro.org. The derived data used to generate the analyses and figures reported here are available at https://doi.org/10.5281/zenodo.5559041

Article and author information

Author details

  1. Christopher J Markiewicz

    Stanford University, Stanford, CA, United States
    Competing interests
    No competing interests declared.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-6533-164X
  2. Krzysztof J Gorgolewski

    Department of Psychology, Stanford University, Stanford, United States
    Competing interests
    No competing interests declared.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-3321-7583
  3. Franklin Feingold

    Stanford University, Stanford, CA, United States
    Competing interests
    No competing interests declared.
  4. Ross Blair

    Stanford University, Stanford, CA, United States
    Competing interests
    No competing interests declared.
  5. Yaroslav O Halchenko

    Dartmouth University, Hanover, NH, United States
    Competing interests
    No competing interests declared.
  6. Eric Miller

    Squishymedia, Portland, OR, United States
    Competing interests
    Eric Miller, EM is owner of Squishymedia which is funded to perform software development work on OpenNeuro..
  7. Nell Hardcastle

    Squishymedia, Portland, OR, United States
    Competing interests
    Nell Hardcastle, NH is an employee of Squishymedia which is funded to perform software development work on OpenNeuro..
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-3837-0707
  8. Joe Wexler

    Department of Psychology, Stanford University, Stanford, United States
    Competing interests
    No competing interests declared.
  9. Oscar Esteban

    Stanford University, Stanford, CA, United States
    Competing interests
    No competing interests declared.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8435-6191
  10. Mathias Goncavles

    Department of Psychology, Stanford University, Stanford, United States
    Competing interests
    No competing interests declared.
  11. Anita Jwa

    Department of Psychology, Stanford University, Stanford, United States
    Competing interests
    No competing interests declared.
  12. Russell Poldrack

    Department of Psychology, Stanford University, Stanford, United States
    For correspondence
    russpold@stanford.edu
    Competing interests
    No competing interests declared.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-6755-0259

Funding

National Institute of Mental Health (R24MH117179)

  • Russell Poldrack

National Institute of Mental Health (R24MH114705)

  • Russell Poldrack

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Copyright

© 2021, Markiewicz et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

Metrics

  • 5,381
    views
  • 528
    downloads
  • 183
    citations

Views, downloads and citations are aggregated across all versions of this paper published by eLife.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Open citations (links to open the citations from this article in various online reference manager services)

Cite this article (links to download the citations from this article in formats compatible with various reference manager tools)

  1. Christopher J Markiewicz
  2. Krzysztof J Gorgolewski
  3. Franklin Feingold
  4. Ross Blair
  5. Yaroslav O Halchenko
  6. Eric Miller
  7. Nell Hardcastle
  8. Joe Wexler
  9. Oscar Esteban
  10. Mathias Goncavles
  11. Anita Jwa
  12. Russell Poldrack
(2021)
The OpenNeuro resource for sharing of neuroscience data
eLife 10:e71774.
https://doi.org/10.7554/eLife.71774

Share this article

https://doi.org/10.7554/eLife.71774

Further reading

    1. Neuroscience
    GVS Devakinandan, Mark Terasaki, Adish Dani
    Research Article

    Specialized chemosensory signals elicit innate social behaviors in individuals of several vertebrate species, a process that is mediated via the accessory olfactory system (AOS). The AOS comprising the peripheral sensory vomeronasal organ has evolved elaborate molecular and cellular mechanisms to detect chemo signals. To gain insight into the cell types, developmental gene expression patterns, and functional differences amongst neurons, we performed single-cell transcriptomics of the mouse vomeronasal sensory epithelium. Our analysis reveals diverse cell types with gene expression patterns specific to each, which we made available as a searchable web resource accessed from https://www.scvnoexplorer.com. Pseudo-time developmental analysis indicates that neurons originating from common progenitors diverge in their gene expression during maturation with transient and persistent transcription factor expression at critical branch points. Comparative analysis across two of the major neuronal subtypes that express divergent GPCR families and the G-protein subunits Gnai2 or Gnao1, reveals significantly higher expression of endoplasmic reticulum (ER) associated genes within Gnao1 neurons. In addition, differences in ER content and prevalence of cubic membrane ER ultrastructure revealed by electron microscopy, indicate fundamental differences in ER function.

    1. Medicine
    2. Neuroscience
    Chi Zhang, Qian Huang ... Yun Guan
    Research Article

    Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for managing post-surgical pain. Local application of Clarix Flo (FLO), a human amniotic membrane (AM) product, attenuated established post-surgical pain hypersensitivity without exhibiting known side effects of opioid use in mice. This effect was achieved through direct inhibition of nociceptive dorsal root ganglion (DRG) neurons via CD44-dependent pathways. We further purified the major matrix component, the heavy chain-hyaluronic acid/pentraxin 3 (HC-HA/PTX3) from human AM that has greater purity and water solubility than FLO. HC-HA/PTX3 replicated FLO-induced neuronal and pain inhibition. Mechanistically, HC-HA/PTX3-induced cytoskeleton rearrangements to inhibit sodium current and high-voltage activated calcium current on nociceptive DRG neurons, suggesting it is a key bioactive component mediating pain relief. Collectively, our findings highlight the potential of naturally derived biologics from human birth tissues as an effective non-opioid treatment for post-surgical pain. Moreover, we unravel the underlying neuronal mechanisms of pain inhibition induced by FLO and HC-HA/PTX3.