Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent manner
- Spanish National Research Council, Spain
- Icahn School of Medicine at Mount Sinai, United States
- University of Pittsburgh, United States
- Northwestern University, United States
- Imperial College London, United Kingdom
Abstract
The spiking activity of populations of cortical neurons is well described by the dynamics of a small number of population-wide covariance patterns, the 'latent dynamics'. These latent dynamics are largely driven by the same correlated synaptic currents across the circuit that determine the generation of local field potentials (LFP). Yet, the relationship between latent dynamics and LFPs remains largely unexplored. Here, we characterised this relationship for three different regions of primate sensorimotor cortex during reaching. The correlation between latent dynamics and LFPs was frequency-dependent and varied across regions. However, for any given region, this relationship remained stable throughout the behaviour: in each of primary motor and premotor cortices, the LFP-latent dynamics correlation profile was remarkably similar between movement planning and execution. These robust associations between LFPs and neural population latent dynamics help bridge the wealth of studies reporting neural correlates of behaviour using either type of recordings.
Data availability
All data used for this paper are posted on Dryad.
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Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent mannerDryad Digital Repository, doi:10.5061/dryad.xd2547dkt.
Article and author information
Author details
Juan Álvaro Gallego
Funding
National Institute of Neurological Disorders and Stroke (F31-NS092356)
- Matthew G Perich
European Research Council (ERC-2020-StG-949660)
- Juan Álvaro Gallego
National Science Foundation (DGE-1324585)
- Raeed H Chowdhury
National Institute of Neurological Disorders and Stroke (T32-NS086749)
- Raeed H Chowdhury
National Institute of Neurological Disorders and Stroke (NS053603)
- Lee E Miller
National Institute of Neurological Disorders and Stroke (NS074044)
- Lee E Miller
National Institute of Neurological Disorders and Stroke (NS095251)
- Lee E Miller
Comunidad de Madrid (2017-T2/TIC-5263)
- Juan Álvaro Gallego
Ministerio de Ciencia e Innovación (PGC2018-095846-A-I00)
- Juan Álvaro Gallego
Engineering and Physical Sciences Research Council (EP/T020970/1)
- Juan Álvaro Gallego
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Animal experimentation: All surgical and experimental procedures were approved by the Institutional Animal Care and Use Committee (IACUC) of Northwestern University under protocol #IS00000367.
Copyright
© 2022, Gallego-Carracedo et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent manner
eLife 11:e73155.
https://doi.org/10.7554/eLife.73155
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