Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent manner

  1. Cecilia Gallego-Carracedo
  2. Matthew G Perich
  3. Raeed H Chowdhury
  4. Lee E Miller
  5. Juan Álvaro Gallego  Is a corresponding author
  1. Spanish National Research Council, Spain
  2. Icahn School of Medicine at Mount Sinai, United States
  3. University of Pittsburgh, United States
  4. Northwestern University, United States
  5. Imperial College London, United Kingdom

Abstract

The spiking activity of populations of cortical neurons is well described by the dynamics of a small number of population-wide covariance patterns, the 'latent dynamics'. These latent dynamics are largely driven by the same correlated synaptic currents across the circuit that determine the generation of local field potentials (LFP). Yet, the relationship between latent dynamics and LFPs remains largely unexplored. Here, we characterised this relationship for three different regions of primate sensorimotor cortex during reaching. The correlation between latent dynamics and LFPs was frequency-dependent and varied across regions. However, for any given region, this relationship remained stable throughout the behaviour: in each of primary motor and premotor cortices, the LFP-latent dynamics correlation profile was remarkably similar between movement planning and execution. These robust associations between LFPs and neural population latent dynamics help bridge the wealth of studies reporting neural correlates of behaviour using either type of recordings.

Data availability

All data used for this paper are posted on Dryad.

The following data sets were generated

Article and author information

Author details

  1. Cecilia Gallego-Carracedo

    Centre for Automation and Robotics, Spanish National Research Council, Madrid, Spain
    Competing interests
    The authors declare that no competing interests exist.
  2. Matthew G Perich

    Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-9800-2386
  3. Raeed H Chowdhury

    Department of Bioengineering, University of Pittsburgh, Pittsburgh, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0002-5934-919X
  4. Lee E Miller

    Department of Biomedical Engineering, Northwestern University, Evanston, United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-8675-7140
  5. Juan Álvaro Gallego

    Department of Bioengineering, Imperial College London, London, United Kingdom
    For correspondence
    juan-alvaro.gallego@imperial.ac.uk
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-2146-0703

Funding

National Institute of Neurological Disorders and Stroke (F31-NS092356)

  • Matthew G Perich

European Research Council (ERC-2020-StG-949660)

  • Juan Álvaro Gallego

National Science Foundation (DGE-1324585)

  • Raeed H Chowdhury

National Institute of Neurological Disorders and Stroke (T32-NS086749)

  • Raeed H Chowdhury

National Institute of Neurological Disorders and Stroke (NS053603)

  • Lee E Miller

National Institute of Neurological Disorders and Stroke (NS074044)

  • Lee E Miller

National Institute of Neurological Disorders and Stroke (NS095251)

  • Lee E Miller

Comunidad de Madrid (2017-T2/TIC-5263)

  • Juan Álvaro Gallego

Ministerio de Ciencia e Innovación (PGC2018-095846-A-I00)

  • Juan Álvaro Gallego

Engineering and Physical Sciences Research Council (EP/T020970/1)

  • Juan Álvaro Gallego

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Ethics

Animal experimentation: All surgical and experimental procedures were approved by the Institutional Animal Care and Use Committee (IACUC) of Northwestern University under protocol #IS00000367.

Reviewing Editor

  1. Srdjan Ostojic, Ecole Normale Superieure Paris, France

Publication history

  1. Preprint posted: May 31, 2021 (view preprint)
  2. Received: August 18, 2021
  3. Accepted: August 2, 2022
  4. Accepted Manuscript published: August 15, 2022 (version 1)
  5. Version of Record published: September 13, 2022 (version 2)

Copyright

© 2022, Gallego-Carracedo et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Cecilia Gallego-Carracedo
  2. Matthew G Perich
  3. Raeed H Chowdhury
  4. Lee E Miller
  5. Juan Álvaro Gallego
(2022)
Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent manner
eLife 11:e73155.
https://doi.org/10.7554/eLife.73155
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