Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex
- McLean Hospital, Harvard Medical School, United States
- University of Rochester School of Medicine & Dentistry, United States
- Massachusetts General Hospital, Harvard Medical School, United States
- Medical University of South Carolina, United States
- Translational Neuropscienc lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, United States
- Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, United States
- Department of Psychiatry, New York University at Langone, United States
- Department of Psychiatry, Columbia University Medical Center, United States
Figures
Figure 1
Injection sites.
(A) Location of 8 injection locations in the vlPFC selected for retrograde analysis. Seven cases were analyzed as the main results (red), and one case was used as validation (yellow). Injection …
Figure 2 with 2 supplements
Strength of projections from Salience Network cortical nodes grouped by cytoarchitectonic divisions across cases.
(A) The dACC corresponds to area 24, while the AI is the combination of areas OPAl, Opro, IPro, and AI. Orange bars illustrate cases with injections in area 47/12, green bars in area 45, and blue …
Figure 2—figure supplement 1
Strength of projections from the frontal and insular cortices to different regions of the vlPFC.
Bars are sorted from stronger to weaker projections in each case. Orange bars illustrate cases with injections in area 47/12, green bars in area 45, and blue bars in area 44. Black dots show the …
Figure 2—figure supplement 2
Labeled input neurons following retrograde tracer injections in different vlPFC locations.
(A–G) Injection locations and retrogradely labeled cells in the main vlPFC cases. Each line contains rostral to caudal coronal sections and the respective labeled cells (red dots) from one case. …
Figure 3 with 1 supplement
Anatomical replication and validation of the caudal 47/12 as a salience network node.
(A) Coronal sections and the respective labeled cells (red dots) from the validation retrograde tracing injection in caudal 47/12 (case 4b). 3D models represent the location of coronal slices. (B) …
Figure 3—figure supplement 1
Terminal fields from injections in caudal vlPFC area 47/12 within the dorsomedial thalamus (1 x amplification), sublenticular extended amygdala (1 x), and periaqueductal gray (2 x).
Abbreviations: 3V=3 rd ventricle; Aq = Aqueduct; DT = Dorsomedial thalamus; GPe = Globus pallidus ext.; GPi = Globus pallidus int.; Hyp = Hypothalamus; LV = lateral ventricle; PAG = Periaqueductal …
Figure 4 with 1 supplement
Functional connectivity analysis in the macaque brain.
(A) Average connectivity strength (Fisher’s Z-values) between vlPFC seeds and the dACC and AI masks. Orange bars illustrate cases with injections in area 47/12, green bars in area 45, and blue bars …
Figure 4—figure supplement 1
Macaque fMRI analysis.
(A) dACC and AI masks created for connectivity strength analysis. Coordinates are in the MNI template. (B) Caudal 47/12 seeds for individual monkeys in the macaque MNI template. The panel in the …
Figure 5 with 1 supplement
Functional connectivity analysis in the human brain.
(A) Average connectivity strength (Fisher’s Z-values) between vlPFC seeds and the dACC and AI masks. Orange bars illustrate cases with injections in area 47/12, green bars in area 45, and blue bars …
Figure 5—figure supplement 1
Replication of human fMRI analysis.
(A) dACC and AI masks created for connectivity strength analysis. Coordinates are in the MNI template. (B) Connectivity strength (Fisher’s z-values) between dACC and vlPFC 3 mm seeds. (C) …
Additional files
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Supplementary file 1
ROI centers for fMRI analysis.
- https://cdn.elifesciences.org/articles/76334/elife-76334-supp1-v2.pptx
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Transparent reporting form
- https://cdn.elifesciences.org/articles/76334/elife-76334-transrepform1-v2.pdf
