(A) Representative flowplots gated on IFN-γ/TNF-α dual positive CD4+ and CD8+ T cells. (B) Aggregate data for IFN-γ/TNF-α dual positive CD4+ and CD8+ T cells are shown (HIV-neg, n=14; suppressed, n=16: viremic, n=13). SARS-CoV-2-specific CD4+ and CD8+ T cells producing IFN-γ, TNF-α, and IL-2 cells in various combinations are shown. Pie chart and dot plots for (C) SARS-CoV-2-specific CD4+ and (D) CD8+ T cells. Pie chart represents the mean distribution across subjects of mono-functional, bi-functional, and poly-functional cytokine producing SARS-CoV-2-specific T cells. Size of each pie segment relates to the frequency of a mono-functional, bi-functional, and triple-functional response. Dot plot represents the frequency of combinations of cytokines produced. Wilcoxon test was done among the dot plots using SPICE software (significant p values are highlighted).