Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein

This Excel workbook contains all the data plotted in Figure 2. The different sheets correspond to different panels within the figure. Additional information regarding data collection can be found in the corresponding Methods section. Data were plotted using gnuplot.

This Excel workbook contains all the data plotted in Figure 3. The different sheets correspond to different panels within the figure. Additional information regarding data collection can be found in the corresponding Methods section. Data were plotted using gnuplot.

This Excel workbook contains the peak heights and volumes for residues within IC_1-260 in the TROSY and CLEANEX NMR experiments collected at 10°C. Additional information regarding data collection can be found in the corresponding Methods section. Data were plotted using gnuplot.

This Excel workbook contains the peak heights and volumes for residues within the ¹⁵N-labeled IC_1-88 and ¹⁵N-labeled IC_216-260 constructs upon binding of IC_100-260, IC_160-240, and ¹⁵N-labeled IC_216-260 or ¹⁵N-labeled IC_1-88. Additional information regarding data collection can be found in the corresponding Methods section. Data were plotted using gnuplot.

This Excel workbook contains the data plotted for the SV-AUC experiments as well as the NMR peak volume ratios for binding studies between ¹⁵N-labeled IC_1-88 and ¹⁵N-labeled IC_37-88 with p150_CC1B and NudE_CC. Additional information regarding data collection can be found in the corresponding Methods section. Data were plotted using gnuplot.

This Excel workbook contains the data plotted for the SV-AUC experiments shown in Figure 7. Additional information regarding data collection can be found in the corresponding Methods section. Data were plotted using gnuplot.

This Excel workbook contains the data plotted for the SEC and SV-AUC experiments shown in Figure 8 with individual sheets corresponding to panels within the figure. Additional information regarding data collection can be found in the corresponding Methods section. Data were plotted using gnuplot.

This zipped folder contains the original files of the full raw unedited gel images for the size exclusion chromatography purification of each IC_1-260 subcomplex. There is also a combined image with the uncropped gels with the relevant bands clearly labeled.

This Excel workbook contains the data plotted for the SEC-MALS experiment of IC_FL and the SV-AUC binding experiments shown in Figure 9 with individual sheets corresponding to panels within the figure. Additional information regarding data collection can be found in the corresponding Methods section. Data were plotted using gnuplot.

This zipped folder contains the original file of the full raw unedited gel image for the IMAC fractions of IC_FL. There is also an image with the uncropped gel with the relevant bands clearly labeled. Notice, two batches of IC_FL were purified in tandem.