Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate

  1. Lyndsey Aponik-Gremillion
  2. Yvonne Y Chen
  3. Eleonora Bartoli
  4. Seth R Koslov
  5. Hernan G Rey
  6. Kevin S Weiner
  7. Daniel Yoshor
  8. Benjamin Y Hayden
  9. Sameer A Sheth
  10. Brett L Foster  Is a corresponding author
  1. Department of Neuroscience, Baylor College of Medicine, United States
  2. Department of Health Sciences, Dumke College for Health Professionals, Weber State University, United States
  3. Department of Neurosurgery, Baylor College of Medicine, United States
  4. Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, United States
  5. Department of Neurosurgery, Medical College of Wisconsin, United States
  6. Joint Department of Biomedical Engineering, Medical College of Wisconsin, United States
  7. Department of Psychology, University of California, Berkeley, United States
  8. Department of Neuroscience, University of Minnesota, United States
  9. Center for Magnetic Resonance Research, University of Minnesota, United States
  10. Center for Neural Engineering, University of Minnesota, United States
4 figures and 2 additional files

Figures

Intracranial recordings sites, PCC anatomy, task design, and predicted neural responses.

(A) Anatomical locations, normalized to MNI space, of intracranial sEEG depth electrodes targeting the posterior aspect of the cingulate cortex, with the distal contact of probes containing …

Figure 2 with 1 supplement
Executive condition selectivity of LFP BBG task responses in dPCC.

(A) Location of a representative dPCC electrode in subject N9. (B) Time-frequency spectrogram for electrode in (A) depicting amplitude (% change) dynamics over time for each task condition. …

Figure 2—figure supplement 1
Episodic condition selectivity of LFP BBG task responses in vPCC.

(A) Location of a representative vPCC electrode in subject N12. (B) Time-frequency spectrogram from electrode in (A) depicting amplitude (% change) dynamics over time for each task condition. …

Spatial clustering of LFP BBG responses across PCC.

Mean LFP BBG response for each macro-electrode site within PCC averaged for the executive (search/add) (A/B) and episodic (past/future) (C/D) task conditions during early (task onset to 1000 ms; …

Figure 4 with 1 supplement
Four functional single unit types in dPCC.

(A) Example isolated single unit waveforms. (B) Raster plots and instantaneous firing rate traces for four example isolated single units shown in (A). Example units show distinct functional …

Figure 4—figure supplement 1
Single unit response clustering.

(A) Group averaged firing rate (with s.e.m.) for all isolated units (nunits = 91) across task conditions. Overall, group data showed modest task modulation and condition selectivity. This initial …

Additional files

Supplementary file 1

Subject demographic and electrode information.

Demographic and electrode information is reported for each subject (1-20), including sex (male/female), age at time of experiment (years), total number of PCC electrodes, number of dPCC electrodes, number of vPCC electrodes, and number of microwire probes.

https://cdn.elifesciences.org/articles/80722/elife-80722-supp1-v1.docx
MDAR checklist
https://cdn.elifesciences.org/articles/80722/elife-80722-mdarchecklist1-v1.docx

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