(A) Cartoon illustration of TCR convergence, created with BioRender.com. T cells with different DNA sequences encode the same TCR due to codon degeneracy. (B) Log10-transformed counts of TCRs with different degrees of degeneracies. The x-axis indicates the number of distinct DNA sequences corresponding to the same TCR, or, the ‘degree of degeneracy’. ‘D1’ refers to the sequences without any degeneracy. (C) The proportion of 20 amino acids in TCRs with degeneracies from one to four. Each of the 20 natural amino acids is represented on the x-axis by a one-letter abbreviation. (D) Tumor mutation burden (TMB) and the proportion of public TCRs in convergent TCRs among different cancer types. The upper panel shows the TMB of ovary, kidney, lung, melanoma, and blood cancer types. Cancer types are ordered from the lowest median TMB (left) to the highest median TMB (right). Lower panel shows the ratio of public TCRs among convergent TCRs in the respective cancer types. The sample size of each group: recovered COVID-19 patients (n=38), healthy control (n=50), ovary (n=45), kidney (n=19), lung (n=50), melanomas (n=29), blood (n=53). The statistical significance was calculated by Welch’s t-test.