Top: description of primary and secondary analyses. Bottom: schematic depicting interpretations of changes in examined metrics. Depictions of bundles, axons, and neurites are not drawn to scale. …
Each dot represents a participant, color-coded by group assignment. Dashed lines mark the score cutoffs for the two reading proficiency groups. Since scores are discrete and not unique, some dots …
Correlation coefficients are reported as Spearman’s . p-values were FDR Benjamini–Hochberg adjusted across tests. *p<0.05; **p<0.001; ***p<1e-5. TOWRE, Tests of Word Reading Efficiency composite …
Only metrics associated with a significant between-sites ANOVA (p<0.05) are plotted. For t-tests between sites, *p<0.05, **p<0.01, ***p<1e-03, and ****p<1e-04. SES, socioeconomic status; ICV, …
Model confounds included a spline fit for age and linear fits for sex, site, neighbor correlation, and log(ICV). Top and bottom panels are left and right hemispheres, respectively. Sagittal slices …
Model confounds included a spline fit for age and linear fits for sex, site, neighbor correlation, and log(ICV). Only the left hemisphere is shown. Sagittal slices go from lateral-to-medial. The …
All tracts were in the left hemisphere. Sagittal slices go from lateral-to-medial. Tracts were segmented from and are plotted on top of the fiber orientation distribution (FOD) template.
Model confounds included a spline fit for age and linear fits for sex, site, and neighbor correlation. Additionally, FC included an additional regressor for log(ICV). Only the left hemisphere is …
Model confounds included a spline fit for age and linear fits for sex, site, neighbor correlation, and log(ICV). Only the left hemisphere is shown. Sagittal slices go from lateral-to-medial. The …
Model confounds included a spline fit for age and linear fits for sex, site, neighbor correlation, and log(ICV). Top and bottom panels are the indexes for orientation dispersion (ODI) and neurite …
17 and 93 participants were lacking socioeconomic and WISC scores, respectively, and were ignored for the corresponding rows. Values are listed as mean (standard error of the mean). For group …
Metric | All (n = 983) | TR (n = 570) | RD (n = 102) | Effect size |
---|---|---|---|---|
Sex (M/F) | 617/366 | 355/215 | 59/43 | Φ = 0.0235 |
Age (years) | 11.16 (0.10) | 11.38 (0.14) | 10.56 (0.27) | d = 0.258* |
Handedness (EHI) | 61.78 (1.58) | 62.19 (2.05) | 62.91 (5.05) | d = 0.015 |
Handedness (L/A/R) | 74/128/781 | 42/66/462 | 8/17/77 | Φ = 0.047 |
SES (years parental edu.) | 17.63 (0.10) | 18.13 (0.11) | 16.93 (0.32) | d = 0.429† |
ICV (cm3) | 1540 (5.130) | 1559 (6.735) | 1501 (12.47) | d = 0.370† |
WISC VSI | 102.08 (0.552) | 105.72 (0.714) | 97.82 (1.497) | d = 0.494† |
WISC VCI | 104.61 (0.542) | 109.26 (0.658) | 98.18 (1.414) | d = 0.750† |
TOWRE | 97.93 (0.56) | 109.49 (0.45) | 70.48 (0.80) | d = 3.74† |
Global FD | 0.285 (6.26e-4) | 0.287 (7.66e-4) | 0.280 (2.53e-3) | d = 0.337* |
Global log(FC) | 0.050 (2.15e-3) | 0.059 (2.73e-3) | 0.030 (5.92e-3) | d = 0.455† |
Mean motion (mm) | 0.44 (7.89e-3) | 0.44 (0.01) | 0.44 (0.03) | d = 4.27e-3 |
Quality (Neighbor Corr.) | 0.756 (1.58e-3) | 0.760 (2.08e-3) | 0.745 (5.17e-3) | d = 0.291* |
TR = typically reading group; RD = reading disability group; EHI = Edinburgh Handedness Inventory; SES = socioeconomic status; ICV = intracranial volume; TOWRE = Tests of Word Reading Efficiency composite score, age-normalized; WISC VSI = Wechsler Intelligence Scale for Children visuospatial index, age-normalized; WISC VCI = Wechsler Intelligence Scale for Children verbal comprehension index, age-normalized; FD = fiber density; FC = fiber cross-section. FD and FC are unitless.
The number of fixels is present for two significance thresholds. For tracts that exist bilaterally, results are given in the form of left/right. Tracts in which the maximum effect size () exceeded …
Tract | N fixels () | N fixels () | Max effect size () |
---|---|---|---|
AF | 2446/1571 | 186/0 | 0.030/0.020 |
ATR | 114/297 | 0/0 | 0.017/0.017 |
CA | 314 | 2 | 0.018 |
CC_1 | 53 | 0 | 0.015 |
CC_2 | 1351 | 0 | 0.018 |
CC_3 | 197 | 0 | 0.015 |
CC_4 | 1770 | 3 | 0.021 |
CC_5 | 1484 | 0 | 0.015 |
CC_6 | 2022 | 32 | 0.024 |
CC_7 | 250 | 0 | 0.018 |
CG | 298/227 | 0/0 | 0.018/0.019 |
CST | 2561/1789 | 90/109 | 0.024/0.024 |
FPT | 3171/2809 | 214/221 | 0.024/0.024 |
FX | 348/300 | 6/6 | 0.024/0.024 |
ICP | 675/614 | 2/25 | 0.023/0.022 |
IFOF | 1205/1056 | 26/0 | 0.024/0.018 |
ILF | 811/422 | 27/0 | 0.021/0.019 |
MCP | 2043 | 22 | 0.022 |
MLF | 1631/824 | 101/0 | 0.029/0.020 |
OR | 585/596 | 18/0 | 0.021/0.016 |
POPT | 2785/2103 | 118/119 | 0.024/0.021 |
SCP | 1453/1378 | 85/76 | 0.029/0.021 |
SLF I | 668/903 | 5/4 | 0.019/0.020 |
SLF II | 918/1015 | 50/0 | 0.029/0.020 |
SLF III | 741/415 | 116/0 | 0.030/0.019 |
ST_FO | 185/125 | 0/0 | 0.019/0.013 |
ST_OCC | 862/872 | 26/2 | 0.024/0.018 |
ST_PAR | 1857/1295 | 15/0 | 0.024/0.020 |
ST_POSTC | 1463/582 | 9/0 | 0.020/0.016 |
ST_PREC | 1854/671 | 17/2 | 0.024/0.016 |
ST_PREF | 825/537 | 0/0 | 0.019/0.017 |
ST_PREM | 214/95 | 0/0 | 0.019/0.018 |
STR | 1035/531 | 3/2 | 0.017/0.014 |
T_OCC | 625/617 | 17/0 | 0.021/0.017 |
T_PAR | 1436/685 | 4/0 | 0.020/0.016 |
T_POSTC | 1086/383 | 0/0 | 0.017/0.015 |
T_PREC | 1497/607 | 5/2 | 0.021/0.014 |
T_PREF | 748/505 | 0/0 | 0.018/0.017 |
T_PREM | 51/143 | 0/0 | 0.012/0.014 |
UF | 665/406 | 23/0 | 0.021/0.016 |
.
AF = arcuate fasciculus; MLF = middle longitudinal fasciculus; SCP = superior cerebellar peduncles; SLF = superior longitudinal fasciculus.
Please refer to Figure 3 of the TractSeg publication (Wasserthal et al., 2018a) for a full list of the tract abbreviations.
ANOVA results for site-wise comparisons between phenotypic and neuroimaging metrics.
Group comparison columns list significant t-statistics. *p<0.05 for the ANOVA between all sites. Post hoc t-tests were only run if the between-sites ANOVA was significant. Only significant t-statistics (p<0.05) are shown in the table. A positive t-statistic denotes Site 1 > Site 2. EHI, Edinburgh Handedness Inventory; SES, socioeconomic status; ICV, intracranial volume; TOWRE, Tests of Word Reading Efficiency composite score, age-normalized; WISC VSI, Wechsler Intelligence Scale for Children visuospatial index, age-normalized; WISC VCI, Wechsler Intelligence Scale for Children verbal comprehension index, age-normalized; gFD, globally averaged fiber density; gFC, globally averaged fiber cross-section.