Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma
- Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, West China Medical School, Sichuan University, China
- Institute of Clinical Pathology, West China Hospital, Sichuan University, China
- Research Core Facility of West China Hospital, Sichuan University, China
- West China Biomedical Big Data Center, West China Hospital, Sichuan University, China
- Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Canada
- Department of Biotherapy and National Clinical Research Center for Geriatrics, Cancer Center, West China Hospital, Sichuan University, China
- MinSheng Ear-Nose-Throat Hospital, China
- Department of Laboratory Medicine, West China Hospital, Sichuan University, China
- Department of Biostatistics, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, Canada
- Department of Medicine, Division of Medical Oncology and Hematology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Canada
Decision letter
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Kellie N SmithReviewing Editor; The Johns Hopkins University School of Medicine, United States
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Tadatsugu TaniguchiSenior Editor; University of Tokyo, Japan
Our editorial process produces two outputs: (i) public reviews designed to be posted alongside the preprint for the benefit of readers; (ii) feedback on the manuscript for the authors, including requests for revisions, shown below. We also include an acceptance summary that explains what the editors found interesting or important about the work.
Decision letter after peer review:
Thank you for submitting your article "Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma" for consideration by eLife. Your article has been reviewed by 1 peer reviewer, and the evaluation has been overseen by a Reviewing Editor and Tadatsugu Taniguchi as the Senior Editor. The reviewer has opted to remain anonymous.
The Reviewing Editor has drafted this to help you prepare a revised submission.
Essential revisions:
1) Temper some claims as indicated in the reviewer comments, ensuring that the conclusions are supported by the data presented.
2) Clarify the use of TCRseq to ensure TCR-based conclusions are biologically relevant.
https://doi.org/10.7554/eLife.82705.sa1Author response
Essential revisions:
1) Temper some claims as indicated in the reviewer comments, ensuring that the conclusions are supported by the data presented.
2) Clarify the use of TCRseq to ensure TCR-based conclusions are biologically relevant.
With the kind help from you, the paper has been carefully revised and all the comments are fully dealt with. Specifically, we have tempered some claims as indicated in the reviewers’ comments, ensuring that the conclusions are supported by the data presented. And we especially clarified the use of TCRseq to ensure TCR-based conclusions are biologically relevant.
https://doi.org/10.7554/eLife.82705.sa2Download links
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Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma
eLife 12:e82705.
https://doi.org/10.7554/eLife.82705
