Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes
- Department of Ecology and Evolutionary Biology, Princeton University, United States
- Princeton Neuroscience Institute, Princeton University, United States
- Laboratory of Fundamental and Applied Entomology, Université Joseph Ki-Zerbo, Burkina Faso
- Department of Livestock Sciences and Techniques, Sine Saloum University El Hadji Ibrahima NIASS, Senegal
- Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana
- Department of Entomology. Center for Vector Biology & Zoonotic Diseases. The Connecticut Agricultural Experiment Station, United States
- Yale University, United States
- Verily Life Sciences, United States
Figures
Figure 1
Dating the origin and spread of the human-specialist form of Aedes aegypti.
(A) The human-specialist form of Aedes aegypti aegypti (Aaa) is thought to have originated in West Africa, before invading the Americas in association with the Atlantic Slave Trade and subsequently …
Figure 2 with 1 supplement
A calibrated coalescent scaling factor for Ae. aegypti suggests rapid evolution of human specialists at the end of the African Humid Period.
(A–B) Calibration of a coalescent scaling factor for Ae. aegypti. (A), The Bhattacharyya coefficient reveals the extent of overlap between the timing of the Atlantic Slave Trade (based on historical …
Figure 2—figure supplement 1
Full detail of cross-coalescent analyses comparing the Sahelian human specialists to invasive human specialists or nearby generalists.
For each population pair (i.e. column), we show MSMC2-inferred changes in effective population size over time (A–D), MSMC2-inferred relative cross-coalescence (expected to plateau at 1 when …
Figure 3 with 2 supplements
Long tracts of human-specialist ancestry in rapidly growing cities suggest a recent influx associated with modern urbanization.
(A–B) f3 analysis confirming that Kumasi, Ghana (A, KUM) and Ouagadougou, Burkina Faso (B, OGD) can be modeled as a product of admixture between generalist and human-specialist Ae. aegypti …
Figure 3—figure supplement 1
Simulations confirm the reliability of admixture analyses in West African cities.
(A–D) AncestryHMM (AHMM) analysis (top row of each panel) reliably detected simulated tracts of BKK ancestry (bottom row of each panel) in a OHI background with tract lengths of 500 kb (A), 1 Mb (B),…
Figure 3—figure supplement 2
Tracts of human-specialist ancestry are concentrated in similar parts of the genome in Kumasi and Ouagadougou.
(A–B) Local fraction of ancestry derived from human specialists across the genome in KUM (A) and OGD (B) (using BKK and OHI as specialist and generalist reference panels, respectively). (C) As in …
Figure 4
Three epochs define the origin and spread of the human-specialist form of Ae. aegypti.
Our analyses suggest that human-specialized Ae. aegypti rapidly diverged from their generalist counterparts after the end of the African Humid Period, with the emergence of settled human societies …
