Internal neural states influence the short-term effect of monocular deprivation in human adults.
- Wenzhou Medical University, China
- Chinese Academy of Sciences, China
- McGill University, Canada
Abstract
The adult human visual system maintains the ability to be altered by sensory deprivation. What has not been considered is whether the internal neural states modulate visual sensitivity to short-term monocular deprivation. In this study we manipulated the internal neural state and reported changes in intrinsic neural oscillations with a patched eye open or closed. We investigated the influence of eye open/eye closure on the unpatched eye's contrast sensitivity and ocular dominance (OD) shifts induced by short-term monocular deprivation. The results demonstrate that internal neural states influence not only baseline contrast sensitivity but also the extent to which the adult visual system can undergo changes in ocular dominance.
Data availability
All data generated or analysed during this study are included in the manuscript and supporting file.
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Funding
National Natural Science Foundation of China (31970975)
- Jiawei Zhou
National Science and Technology Major Project (2022ZD0211900)
- Peng Zhang
National Science and Technology Major Project (2021ZD0204200)
- Peng Zhang
Natural Science Foundation for Distinguished Young scholars of zhejiang Province (LR22H120001)
- Jiawei Zhou
Project of State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University (J02-20210203)
- Jiawei Zhou
Canadian Institutes of Health Research (CCI-125686)
- Robert F Hess
Natural Sciences and Engineering Research Council of Canada (228103)
- Robert F Hess
ERA-NET Neuron (JTC2015)
- Robert F Hess
National Natural Science Foundation of China (31871107)
- Peng Zhang
National Natural Science Foundation of China (31930053)
- Peng Zhang
Project of State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University (K03-20220102)
- Peng Zhang
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Ethics
Human subjects: This study complied with the Declaration of Helsinki and was approved by the Institutional Review Boards of Wenzhou Medical University. The methods were carried out in accordance with the approved guidelines under the protocol 'Adult amblyopia: binocular visual deficits and rehabilitation' version #1 dated 5/29/2019. All subjects were naive to the purpose of the study, and provided written informed consent which included consent to process and preserve the data and publish them in anonymous form.
Copyright
© 2023, Chen et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Internal neural states influence the short-term effect of monocular deprivation in human adults.
eLife 12:e83815.
https://doi.org/10.7554/eLife.83815
