Sex-dependent noradrenergic modulation of premotor cortex during decision-making

  1. Ellen M Rodberg
  2. Carolina R den Hartog
  3. Emma S Dauster
  4. Elena M Vazey  Is a corresponding author
  1. Neuroscience and Behavior Program and Department of Biology, University of Massachusetts Amherst, United States
6 figures and 1 additional file

Figures

Propranolol decreased goal-directed task participation, particularly in females.

(A) Schematic of events in the two-alternative forced-choice (2AFC) task (L–R). (1) Rats self-initiated trials by breaking an IR beam in the central well. (2) After a variable length (200–700 ms) IR …

Propranolol influences basal properties of female anterior M2 neurons.

(A) Placements of the center of electrode array in M2 in females (yellow circle) and males (orange star). (B) Representative figure of histological placement of microelectrode array in M2. Tissue is …

Propranolol decreases active inhibition of nonpreferred action plans.

(A) Anterior M2 neurons show differential responses to opposing cue presentations. Raster (above) and perievent histogram of a single representative neuron aligned to cue onset (t = 0 s, 100 ms …

Propranolol decreases action plan representation prior to lever press.

(A) Example differential responses to preferred and nonpreferred lever press. Raster (above) and perievent histogram aligned to lever press response (at t = 0 s,100 ms bins) from 3 s before lever …

Females express higher levels of β-adrenoreceptor RNA in anterior M2.

(A) Representative figure of RNAscope labeling in anterior M2 (n=8 hemispheres, 4 animals per group) of female (top) and male (bottom) rodents. β2 RNA expression (magenta) in M2 with DAPI (blue) …

Author response image 1
Motivation, as measured by the number of self-initiated trials in the 2AFC task decreased over time after saline but neural representation of action plans did not.

Top: The number of self-initiated trials binned in 5-minute increments and plotted across the 40-minute session. Males (open circle) and females (closed circle) start with high rates of trial …

Additional files

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