(A) Schematic of events in the two-alternative forced-choice (2AFC) task (L–R). (1) Rats self-initiated trials by breaking an IR beam in the central well. (2) After a variable length (200–700 ms) IR …
Two-alternative forced-choice (2AFC) behavior.
(A) Placements of the center of electrode array in M2 in females (yellow circle) and males (orange star). (B) Representative figure of histological placement of microelectrode array in M2. Tissue is …
M2 basal neural activity.
(A) Anterior M2 neurons show differential responses to opposing cue presentations. Raster (above) and perievent histogram of a single representative neuron aligned to cue onset (t = 0 s, 100 ms …
Cue-evoked M2 activity.
(A) Example differential responses to preferred and nonpreferred lever press. Raster (above) and perievent histogram aligned to lever press response (at t = 0 s,100 ms bins) from 3 s before lever …
Lever press-aligned M2 activity.
(A) Representative figure of RNAscope labeling in anterior M2 (n=8 hemispheres, 4 animals per group) of female (top) and male (bottom) rodents. β2 RNA expression (magenta) in M2 with DAPI (blue) …
M2 RNAscope.
Top: The number of self-initiated trials binned in 5-minute increments and plotted across the 40-minute session. Males (open circle) and females (closed circle) start with high rates of trial …