(A) Sankey plot shows overlap of CCCRC subtypes with the three-category immune classification system (‘desert’, ‘excluded’, and ‘inflamed’ phenotypes), and their representative hematoxylin and eosin (HE)-stained whole-slide images (WSIs). C1: TCGA-AA-3955; C2: TCGA-A6-6654; C3: TCGA-CK-4948; and C4: TCGA-AD-6963. Scale bars 200 μm.(B) Representative WSI (top) and the colorectal cancer (CRC)-multiclass model-inference segmentation of eight tissue types: tumor, stroma, lymphocyte, normal colon mucosa, debris, adipose, mucin, and muscle (bottom). Scale bar 500 μm. Box plots show differences in the abundance of tumors (C), lymphocyte infiltration (lym) (D), and stroma (E) in the core tumor (CT) region. Box plots show differences in the lymphocyte infiltration to tumor content ratio (F) and lymphocyte infiltration to stromal content ratio (G) in the CT region. Box plots show differences in the abundance of lymphocytes infiltration (H) and stroma (I) in the invasive margin (IM) region. (J) Box plots show differences in the ratio of lymphocyte infiltration in the IM region to the CT region.