Transcranial focused ultrasound to human rIFG improves response inhibition through modulation of the P300 onset latency
- Baylor College of Medicine, United States
- Arizona State University, United States
- University of Alabama at Birmingham, United States
Abstract
Response inhibition in humans is important to avoid undesirable behavioral action consequences. Neuroimaging and lesion studies point to a locus of inhibitory control in the right inferior frontal gyrus (rIFG). Electrophysiology studies have implicated a downstream event-related potential from rIFG, the fronto-central P300, as a putative neural marker of the success and timing of inhibition over behavioral responses. However, it remains to be established whether rIFG effectively drives inhibition and which aspect of P300 activity uniquely indexes inhibitory control-ERP timing or amplitude. Here, we dissect the connection between rIFG and P300 for inhibition by using transcranial-focused ultrasound (tfUS) to target rIFG of human subjects while they performed a Stop-Signal task. By applying tFUS simultaneously with different task events, we found behavioral inhibition was improved, but only when applied to rIFG simultaneously with a 'stop' signal. Improved inhibition through tFUS to rIFG was indexed by faster stopping times that aligned with significantly shorter N200/P300 onset latencies. In contrast, P300 amplitude was modulated during tFUS across all groups without a paired change in behavior. Using tFUS, we provide evidence for a causal connection between anatomy, behavior, and electrophysiology underlying response inhibition.
Data availability
The human behavioral and EEG ERP datasets for reproducing figures are publicly available. The datasets are publicly available on Dryad: shorturl.at/BOWX6Dryad Digital Repository, doi:10.5061/dryad.sj3tx968j
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Transcranial focused ultrasound to rIFG improves response inhibition through modulation of the P300 onset latencyDryad Digital Repository, doi:10.5061/dryad.sj3tx968j.
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Funding
The authors declare there was no funding of this work.
Ethics
Human subjects: Informed consent, safety checklists, and right to publish data were obtained from each participant in the study. All study procedures were approved and performed in accordance with the institutional review board at Arizona StateUniversity (STUDY00006050).
Copyright
© 2023, Fine et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Transcranial focused ultrasound to human rIFG improves response inhibition through modulation of the P300 onset latency
eLife 12:e86190.
https://doi.org/10.7554/eLife.86190
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