Figures and data in Region of Attainable Redaction, an extension of Ellipse of Insignificance analysis for gauging impacts of data redaction in dichotomous outcome trials

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Tables
Additional files

2 figures, 2 tables and 2 additional files

Figures

Figure 1

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ROAR analysis implementation example.

(a) A simulated example of the Region of Attainable Redaction (ROAR) for $a = 70$ , $b = 30$ , $c = 50$ , $d = 50$ ( $R R_{E} > 1$ ) with all points bounded by the shaded region depict a degree of redaction which would not lead to the null being rejected. (b) Relevant vectors for ascertaining possible redaction thresholds in $R R_{E} > 1$ case. (c) ROAR analysis of the similar data but with ( $R R_{E} < 1$ ) ( $a = 50$ , $b = 50$ , $c = 70$ , $d = 30$ ). Note that $R R_{E} > 1$ case is a transform of $R R_{E} < 1$ situation. (d) Relevant vectors for ascertaining possible redaction thresholds in case $R R_{e} < 1$ .

Figure 2

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ROAR example for large data-set.

(a) A simulated example of the Region of Attainable Redaction (ROAR) for a meta-analysis of $N = 39, 197$ as described in the text. (b) Relevant vectors for ascertaining possible redaction thresholds.

Tables

Table 1

Reported groups and related variables.

Redaction for $R R_{e} > 1$
	Endpoint positive	Endpoint negative
Experimental group	$a$	$b + x$
Control group	$c + y$	$d$
Redaction for $R R_{e} < 1$
	Endpoint positive	Endpoint negative
Experimental group	$a + x$	$b$
Control group	$c$	$d + y$

Table 2

ROAR-derived metrics for published data (see ‘Results’ for details).

Statistics for simulated example case
ROAR statistic ( $α = 0.05$ )	Calculated ROAR value (simulated $R R_{E} > 1$ data)	Calculated ROAR value (simulated $R R_{E} < 1$ data)
Total subjects reported $N$	200	200
Relative risk (95% CI) $R R_{E}$	1.40 (1.11–1.77)	0.60 (0.46–0.76)
FOCK point	$(x_{e}, y_{e}) = (6.89, 4.79)$	$(x_{e}, y_{e}) = (4.79, 6.89)$
$r_{m i n}$	12 subjects	12 subjects
Experimental redaction tolerance $ρ_{E}$	9.51% ( $⌈ x_{c} ⌉$ = 10 subjects)	14.32% ( $⌈ x_{c} ⌉$ = 14 subjects)
Control redaction tolerance $ρ_{C}$	14.32% ( $⌈ y_{c} ⌉$ = 16 subjects)	9.51% ( $⌈ y_{c} ⌉$ = 10 subjects)
Total redaction tolerance $ρ_{A}$	5.66% (12 subjects)	5.66% (12 subjects)
Statistics for large meta-analysis
ROAR statistic ( $α = 0.05$ )	Calculated ROAR value
Total subjects reported $N$	39,197
Relative risk (95% CI)	0.85 (0.74–0.97)
FOCK point	$(x_{e}, y_{e}) = (14.17, 0.32)$
$r_{m i n}$	14 subjects
Experimental redaction tolerance $ρ_{E}$	0.07% (13 subjects)
Control redaction tolerance $ρ_{C}$	3.21% (649 subjects)
Total redaction tolerance $ρ_{A}$	0.04% (14 subjects)

FOCK, Fewest Observations/Censored Knowledge; ROAR, Region of Attainable Redaction.

Additional files

MDAR checklist: https://cdn.elifesciences.org/articles/93050/elife-93050-mdarchecklist1-v2.docx
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Supplementary file 1 Coefficients for $g (x, y)$ (Table S1) and related identity $h (x, y)$ (Table S2).: https://cdn.elifesciences.org/articles/93050/elife-93050-supp1-v2.pdf
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David Robert Grimes

(2024)

Region of Attainable Redaction, an extension of Ellipse of Insignificance analysis for gauging impacts of data redaction in dichotomous outcome trials

eLife 13:e93050.

https://doi.org/10.7554/eLife.93050