Region of Attainable Redaction, an extension of Ellipse of Insignificance analysis for gauging impacts of data redaction in dichotomous outcome trials
Figures
Figure 1
![](https://iiif.elifesciences.org/lax:93050%2Felife-93050-fig1-v2.tif/full/617,/0/default.jpg)
ROAR analysis implementation example.
(a) A simulated example of the Region of Attainable Redaction (ROAR) for , , , () with all points bounded by the shaded region depict a degree of redaction which would not lead to the null being rejected. (b) Relevant vectors for ascertaining possible redaction thresholds in case. (c) ROAR analysis of the similar data but with () (, , , ). Note that case is a transform of situation. (d) Relevant vectors for ascertaining possible redaction thresholds in case .
Tables
Table 1
Reported groups and related variables.
Redaction for | ||
---|---|---|
Endpoint positive | Endpoint negative | |
Experimental group | ||
Control group | ||
Redaction for | ||
Endpoint positive | Endpoint negative | |
Experimental group | ||
Control group |
Table 2
ROAR-derived metrics for published data (see ‘Results’ for details).
Statistics for simulated example case | ||
---|---|---|
ROAR statistic () | Calculated ROAR value (simulated data) | Calculated ROAR value (simulated data) |
Total subjects reported | 200 | 200 |
Relative risk (95% CI) | 1.40 (1.11–1.77) | 0.60 (0.46–0.76) |
FOCK point | ||
12 subjects | 12 subjects | |
Experimental redaction tolerance | 9.51% ( = 10 subjects) | 14.32% ( = 14 subjects) |
Control redaction tolerance | 14.32% ( = 16 subjects) | 9.51% ( = 10 subjects) |
Total redaction tolerance | 5.66% (12 subjects) | 5.66% (12 subjects) |
Statistics for large meta-analysis | ||
ROAR statistic () | Calculated ROAR value | |
Total subjects reported | 39,197 | |
Relative risk (95% CI) | 0.85 (0.74–0.97) | |
FOCK point | ||
14 subjects | ||
Experimental redaction tolerance | 0.07% (13 subjects) | |
Control redaction tolerance | 3.21% (649 subjects) | |
Total redaction tolerance | 0.04% (14 subjects) |
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FOCK, Fewest Observations/Censored Knowledge; ROAR, Region of Attainable Redaction.
Additional files
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MDAR checklist
- https://cdn.elifesciences.org/articles/93050/elife-93050-mdarchecklist1-v2.docx
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Supplementary file 1
Coefficients for (Table S1) and related identity (Table S2).
- https://cdn.elifesciences.org/articles/93050/elife-93050-supp1-v2.pdf
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Region of Attainable Redaction, an extension of Ellipse of Insignificance analysis for gauging impacts of data redaction in dichotomous outcome trials
eLife 13:e93050.
https://doi.org/10.7554/eLife.93050