Figure 4—figure supplement 1. | Splicing repression allows the gradual emergence of new Alu-exons in primate evolution

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Splicing repression allows the gradual emergence of new Alu-exons in primate evolution

Figure 4—figure supplement 1.

Affiliation details

UCL Institute of Neurology, United Kingdom; MRC-Laboratory of Molecular Biology, United Kingdom; Institute de Biologie de l’ENS (IBENS), CNRS UMR 8197, France; University College London Genetics Institute, United Kingdom; Goethe University Frankfurt, Germany; Institute of Molecular Biology (IMB), Germany
Figure 4—figure supplement 1.
Download figureOpen in new tabFigure 4—figure supplement 1. Repression of Alu-exons in dependence of U-tract length.

All Alu-exons in protein-coding genes that are validated by junction-spanning reads at both the 5' and the 3' splice site (SS) were selected. Boxplots showing the changes in exon abundance upon hnRNPC and/or UPF1 depletion as fold changes (log2; log2FC) over control, in dependence of the length of the U-tract preceding the 3' splice site. U-tracts ranged from 3 to 30 continuous uridine nucleotides, with exons preceded by U-tracts of 20 or more uridines grouped together.

DOI: http://dx.doi.org/10.7554/eLife.19545.016