Figure 3. | On cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus

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On cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus

Figure 3.

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Federal University of Rio Grande do Norte, Brazil
Figure 3.
Download figureOpen in new tabFigure 3. True n:m phase-locking leads to significant Rn:m values.

(A) The left panels show mean Rn:m curves and distributions of R1:5 values for original and surrogate (Random Permutation/Single Run) data obtained from the simulation of two coupled Kuramoto oscillators (n = 300; epoch length = 30 s; *p<0.001, t-test). The right panels show the same, but for uncoupled oscillators. In these simulations, each oscillator has instantaneous peak frequency determined by a Gaussian distribution; the mean natural frequencies of the theta and gamma oscillators were set to 8 Hz and 40 Hz, respectively (coupling does not alter the mean frequencies since they already exhibit a 1:5 ratio; compare with Figure 1). (B) Top panels show results from a simulation of a model network composed of two mutually connected interneurons, O and I cells, which emit spikes at theta and gamma frequency, respectively (Tort et al., 2007; Kopell et al., 2010). Original n:m phase-locking levels are significantly higher than chance (n = 300; epoch length = 30 s; *p<0.001, t-test). The bottom panels show the same, but for unconnected interneurons. In this case, n:m phase-locking levels are not greater than chance.

DOI: http://dx.doi.org/10.7554/eLife.20515.009