4 results found
    1. Cell Biology

    Oscillatory phase separation in giant lipid vesicles induced by transmembrane osmotic differentials

    Kamila Oglęcka, Padmini Rangamani ... Atul N Parikh
    Spontaneous osmoregulation in giant phospholipid vesicles, which is characterized by oscillations in vesicle size and membrane tension, couples to the compositional degrees of freedom at the membrane surface to produce oscillations in domain texture and induce isothermal phase change.
    1. Cancer Biology

    tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

    Myron S Ignatius, Madeline N Hayes ... David M Langenau
    Syngeneic tp53-null zebrafish develop a wide range of tumors that engraft into recipient animals with loss of Tp53 leading to increased metastasis in embryonal rhabdomyosarcoma (ERMS), likely accounting for increased aggression in TP53-inactivated human ERMS.
    1. Developmental Biology

    Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development

    Shahram Jevin Poureetezadi, Christina N Cheng ... Rebecca A Wingert
    Prostaglandin synthesis and PGE2 receptor activity are essential for mediating segmentation of renal progenitors during pronephros formation in the zebrafish.
    1. Immunology and Inflammation

    Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

    Chongbin Hu, Nan Zhang ... Jian-zhong Shao
    scRNA-seq revealed the fish kidney is a dual-functional entity with functionalities of both primary and secondary lymphoid organs and highlighted the multifaced biology of kidney in ancient vertebrates.

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