45 results found
    1. Neuroscience

    Two central pattern generators from the crab, Cancer borealis, respond robustly and differentially to extreme extracellular pH

    Jessica A Haley, David Hampton, Eve Marder
    The rhythms generated by the stomatogastric and cardiac ganglia of the Jonah crab are surprisingly robust but differentially sensitive to acute changes in extracellular pH from pH 5.5 to 10.4.
    1. Neuroscience

    Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion

    Adriane G Otopalik, Marie L Goeritz ... Eve Marder
    Reliable neuronal physiology can arise from variable and inefficient morphologies.
    1. Neuroscience

    When complex neuronal structures may not matter

    Adriane G Otopalik, Alexander C Sutton ... Eve Marder
    Animal-to-animal variability in neuronal geometry may be compensated for by compact electrotonic structure.
    1. Neuroscience

    Neuronal morphologies built for reliable physiology in a rhythmic motor circuit

    Adriane G Otopalik, Jason Pipkin, Eve Marder
    Neurite geometry enables expansive and highly-branched neuronal structures to operate like single electrical compartments and simple linear integrators.
    1. Neuroscience

    Reciprocally inhibitory circuits operating with distinct mechanisms are differently robust to perturbation and modulation

    Ekaterina Morozova, Peter Newstein, Eve Marder
    Nuanced changes in the mechanism of oscillation in reciprocally inhibitory circuits can profoundly alter the circuit stability in response to perturbations and inputs.
    1. Computational and Systems Biology
    2. Neuroscience

    Training deep neural density estimators to identify mechanistic models of neural dynamics

    Pedro J Gonçalves, Jan-Matthis Lueckmann ... Jakob H Macke
    Deep neural networks can be trained to automatically find mechanistic models which quantitatively agree with experimental data, providing new opportunities for building and visualizing interpretable models of neural dynamics.
    1. Neuroscience

    Coupling between fast and slow oscillator circuits in Cancer borealis is temperature-compensated

    Daniel Powell, Sara A Haddad ... Eve Marder
    The mechanism that couples two rhythmic circuits is maintained over a large temperature range although both circuits are temperature-sensitive.
    1. Neuroscience

    Synergistic plasticity of intrinsic conductance and electrical coupling restores synchrony in an intact motor network

    Brian J Lane, Pranit Samarth ... David J Schulz
    Neural networks like the crustacean cardiac ganglion employ multi-faceted compensatory mechanisms to achieve the stability and robustness that are critical to long-term function.
    1. Computational and Systems Biology
    2. Neuroscience

    Mapping circuit dynamics during function and dysfunction

    Srinivas Gorur-Shandilya, Elizabeth M Cronin ... Eve Marder
    Mapping spike patterns from a small identified circuit reveals the diversity and complexity of circuit dynamics across animals and in response to perturbations.
    1. Neuroscience

    Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury

    Akira Sakurai, Arianna N Tamvacakis, Paul S Katz
    Animal-to-animal variability in neural circuit elements is often hidden under normal conditions, but becomes functionally relevant when the system is challenged by injury.

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