Fate mapping of LGE-derived OPCs by combining IUE with PiggyBac transposon system
(A) Schematic of the PiggyBac transposon reporter system used in this study.
(B) The experimental workflow.
(C) Representative coronal sections showing the distribution of GFP+ cells at E18.5.
(D) GFP+ cells expressed NeuN but not glial cell markers, such as OLIG2, SOX10 and PDGFRA in the cortex. However, GFP+ cells expressed NeuN, OLIG2, SOX10 and PDGFRA in the striatum.
(E) GFP+ cells expressed NeuN but not glial cell markers, such as OLIG2, SOX10 and PDGFRA in the cortex and GFP+ cells expressed NeuN, OLIG2, SOX10 and PDGFRA in the striatum at P10.