Computational modeling suggests that the BLA is capable of producing the recorded LFP rhythms via interactions of interneuron subtypes, and that those rhythms may be necessary for associative learning.
E Mae Guthman, Joshua D Garcia ... Molly M Huntsman
Sst+ interneurons drive feedforward inhibition in the basolateral amygdala, and thus provide a framework for why interneuron subtypes may mediate different archetypal circuit motifs across different brain regions.
Timothy P O'Leary, Kaitlin E Sullivan ... Mark S Cembrowski
Basolateral amygdala excitatory neurons are a highly heterogenous collection of neurons that spatially covary in molecular, cellular, and circuit properties.
Gabriela Manzano Nieves, Marilyn Bravo ... Kevin G Bath
Early life adversity (ELA) accelerated PV+ interneuron development in BLA and delayed the ability of pre-adolescent mice to express, but not form, an auditory conditioned fear memory in childhood.
A lineage-based intersectional genetic approach reveals brain-wide distribution and input connectivity of axo-axonic interneuron cells and establishes experimental access to study the circuit function of a ground truth cell type.
Jordan G McCall, Edward R Siuda ... Michael R Bruchas
Selective activation of locus coeruleus noradrenergic terminals drives anxiety-like behaviors through activation of β-adrenergic receptors in the basolateral amygdala.
Robust fear learning deficits and decreased tonic activity of NAc cholinergic interneurons caused by depletion of MeCP2 could be attributed to an elevation in α2-containing GABAA receptors.
Photopharmacological manipulations of mGlu5 receptors with light-sensitive negative allosteric modulators show brain region-specific roles in pain modulation and suggest that blockade of mGlu5 receptors in the amygdala may limit the overall analgesic activity of mGlu5 receptor antagonists.
Jian-You Lin, Narendra Mukherjee ... Donald B Katz
Blocking input from basolateral amygdala to gustatory cortex (GC) severely reduces the coherence of GC ensemble activity, which negatively affects epochal dynamics involved in driving palatability-driven consumption.