65 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Basolateral amygdala oscillations enable fear learning in a biophysical model

    Anna Cattani, Don B Arnold ... Nancy Kopell
    Computational modeling suggests that the BLA is capable of producing the recorded LFP rhythms via interactions of interneuron subtypes, and that those rhythms may be necessary for associative learning.
    1. Neuroscience

    Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition

    E Mae Guthman, Joshua D Garcia ... Molly M Huntsman
    Sst+ interneurons drive feedforward inhibition in the basolateral amygdala, and thus provide a framework for why interneuron subtypes may mediate different archetypal circuit motifs across different brain regions.
    1. Neuroscience

    Prefrontal-amygdalar oscillations related to social behavior in mice

    Nahoko Kuga, Reimi Abe ... Takuya Sasaki
    The dorsal medial prefrontal cortex and basolateral amygdala exhibit social behavior-relevant neuronal oscillations, representing unified pathophysiological mechanisms underlying social behavioral deficits.
    1. Neuroscience

    Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala

    Timothy P O'Leary, Kaitlin E Sullivan ... Mark S Cembrowski
    Basolateral amygdala excitatory neurons are a highly heterogenous collection of neurons that spatially covary in molecular, cellular, and circuit properties.
    1. Neuroscience

    Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development

    Gabriela Manzano Nieves, Marilyn Bravo ... Kevin G Bath
    Early life adversity (ELA) accelerated PV+ interneuron development in BLA and delayed the ability of pre-adolescent mice to express, but not form, an auditory conditioned fear memory in childhood.
    1. Neuroscience

    Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons

    Ricardo Raudales, Gukhan Kim ... Z Josh Huang
    A lineage-based intersectional genetic approach reveals brain-wide distribution and input connectivity of axo-axonic interneuron cells and establishes experimental access to study the circuit function of a ground truth cell type.
    1. Neuroscience

    Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior

    Jordan G McCall, Edward R Siuda ... Michael R Bruchas
    Selective activation of locus coeruleus noradrenergic terminals drives anxiety-like behaviors through activation of β-adrenergic receptors in the basolateral amygdala.
    1. Neuroscience

    MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning

    Ying Zhang, Yi Zhu ... Xiao-Ming Li
    Robust fear learning deficits and decreased tonic activity of NAc cholinergic interneurons caused by depletion of MeCP2 could be attributed to an elevation in α2-containing GABAA receptors.
    1. Neuroscience

    A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs

    Serena Notartomaso, Nico Antenucci ... Volker Neugebauer
    Photopharmacological manipulations of mGlu5 receptors with light-sensitive negative allosteric modulators show brain region-specific roles in pain modulation and suggest that blockade of mGlu5 receptors in the amygdala may limit the overall analgesic activity of mGlu5 receptor antagonists.
    1. Neuroscience

    Perturbation of amygdala-cortical projections reduces ensemble coherence of palatability coding in gustatory cortex

    Jian-You Lin, Narendra Mukherjee ... Donald B Katz
    Blocking input from basolateral amygdala to gustatory cortex (GC) severely reduces the coherence of GC ensemble activity, which negatively affects epochal dynamics involved in driving palatability-driven consumption.

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