Overexpression of hAC8 engages complex, coordinate adaptation 'circuity' that has evolved in mammalian cells to defend against stress that threatens health or life, and may be important for proper healing in disease states such as heart infarction or failure.

Genomics-based evidence support population- and sex-specific selection of an epistatic interaction between genetic variants in ADCY9 and CETP, genes of pharmacogenetic importance in cardiovascular diseases.

Neuronal Calcium Sensor-1 (NCS1) is a protein that captures the preciliary vesicle in the early step of the cilium formation.