Single-nucleus RNA-sequencing of the hypothalamic preoptic area of monogamous and promiscuous deer mouse species reveals neuronal differences that may be responsible for innate changes in mating and parental care behavior.

Preoptic area of the hypothalamus is important for the homeostatic regulation of rapid eye movement sleep.

Warm-activated parabrachial neurons contain overlapping dynorphin and enkephalin expressing subpopulations, project to preoptic hypothalamus, and mediate behavioral and physiological thermal defenses behaviors.

The preoptic area (POA) regulates distinct metabolic adaptations, via leptin-dependent (fasting-induced hypometabolism and high-fat-diet-induced hypermetabolism), or leptin-independent mechanisms (temperature induced metabolic changes) and thus significantly contributes to body weight homeostasis.

Preoptic neurotensinergic neurons co-release GABA and neurotensin, triggering a rapid initial inhibition followed by a sustained excitation, and mice lacking GABA release from these neurons exhibit altered thermoregulation.

Preoptic area neurons co-expressing GABA and kisspeptin are essential for the preovulatory surge mechanism but not for the pulsatile secretion of luteinizing hormone.

In vivo genetic lineage-tracing reveals the developmental trajectory of neurogliaform cells, the main effectors of a powerful inhibitory motif in the neocortex.

Inhibitory neurons in the female medial preoptic area show persistent activity in response to male ejaculation, and their reactivation is sufficient to suppress female sexual motivation.

A neural circuit mechanism explains how chronic extreme heat exposure affects emotions in the mouse model.

Inhibitory neurons in the hypothalamus and amygdala push and pull on the midbrain vocal gating circuit to trigger and suppress ultrasonic vocalization (USV) production in the mouse.