Browse our latest Neuroscience articles

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    1. Neuroscience

    Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity

    Audrey T Medeiros, Scott J Gratz ... Kate M O'Connor-Giles
    In vivo analysis of endogenously tagged Ca2+ channel subunits reveals unexpected differences in subunit composition and synapse-specific relationships between channel abundance and synaptic strength.
    1. Neuroscience

    Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure

    Stefan Passlick, Ghanim Ullah, Christian Henneberger
    Synaptic glutamate release is potentiated by short metabolic failure whereas longer durations of energy depletion lead to a postsynaptic failure of synaptic transmission.
    1. Neuroscience

    Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish

    Moneeza A Agha, Sandeep Kishore, David L McLean
    Unexpected complexity in the synaptic basis of locomotor rhythmogenesis is linked to cell type and speed in larval zebrafish.
    1. Neuroscience

    DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

    Ernie Yulyaningsih, Jung H Suh ... Pascal E Sanchez
    DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.
    1. Neuroscience

    Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes

    Yuan Chang, Savannah Lusk ... Russell S Ray
    Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for baseline breathing and hypercapnic, hypoxic chemosensory reflexes, which challenges the current understanding of central noradrenergic neurons in breathing control.
    1. Neuroscience

    Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons

    Besma Brahmia, Yahaira Naaldijk ... Sabine Hilfiker
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Disrupted Hippocampal Theta-Gamma Coupling and Spike-Field Coherence Following Experimental Traumatic Brain Injury

    Christopher D Adam, Ehsan Mirzakhalili ... John A Wolf
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Language experience shapes predictive coding of rhythmic sound sequences

    Piermatteo Morucci, Sanjeev Nara ... Nicola Molinaro
    A magnetoencephalography study across different languages shows that life-long listening experience influences the neural mechanisms underlying rhythm perception.
    1. Cell Biology
    2. Neuroscience

    CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function

    Longxin Xie, Jessica Merjane ... Christopher J Donnelly
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Neuroscience

    Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis

    Luting Yang, Chunqing Hu ... Yaping Yan
    Cell biology and animal model analysis in mice shows that molecules involved in glycolytic metabolism could potentially serve as therapeutic targets for the treatment of neurological diseases.
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