Browse our latest Neuroscience articles

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    1. Neuroscience

    Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography

    Mingchao Yan, Wenwen Yu ... Zheng Wang
    A comprehensive excitatory projectome of the ventro-lateral prefrontal cortex in macaques was generated by using viral tracing integrated with serial two-photon tomography and diffusion tractography, thus providing new evidence of rejecting the monosynaptic connection of inferior fronto-occipital fasciculus in monkeys.
    1. Neuroscience

    Role of anterior insula cortex in context-induced relapse of nicotine-seeking

    Hussein Ghareh, Isis Alonso-Lozares ... Nathan J Marchant
    The anterior insula cortex is a critical neural substrate of context-induced relapse of nicotine-seeking.
    1. Neuroscience

    A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression

    Jessica H Kim, Grace H Kromm ... Matthew E Carter
    The hypothalamic parasubthalamic nucleus can be subdivided into two distinct populations, one of which decreases food consumption and is necessary for the full appetite-suppressing effects of anorexigenic hormones.
    1. Neuroscience

    Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

    Nataliia Kozhemiako, Jun Wang ... Jen Q Pan
    Multiple non-redundant features of non-rapid eye movement sleep are altered in schizophrenia and largely independent of waking electrophysiological abnormalities, supporting the promise of neuropsychiatric disease biomarkers based on a precise dissection of the sleep.
    1. Neuroscience

    Prefrontal-amygdalar oscillations related to social behavior in mice

    Nahoko Kuga, Reimi Abe ... Takuya Sasaki
    The dorsal medial prefrontal cortex and basolateral amygdala exhibit social behavior-relevant neuronal oscillations, representing unified pathophysiological mechanisms underlying social behavioral deficits.
    1. Neuroscience

    Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse

    Amy Richardson, Victoria Ciampani ... Ian D Forsythe
    The Kv3.3 potassium channel subunit is necessary and sufficient to permit presynaptic location and accelerated repolarisation of the presynaptic action potential, thereby conserving resources and enhancing accuracy of timing information on transmission at the calyx of Held excitatory synapse.
    1. Neuroscience

    Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins

    Dagmara Korona, Benedict Dirnberger ... Kathryn S Lilley
    Blocking of the function of neurotransmitter receptors by insecticidal peptide toxins resulted in identification of nicotinic acetylcholine receptor subunits through native ligand-binding investigations.
    1. Genetics and Genomics
    2. Neuroscience

    Machine learning sequence prioritization for cell type-specific enhancer design

    Alyssa J Lawler, Easwaran Ramamurthy ... Andreas R Pfenning
    A new cross-species machine learning-based strategy is applied to find enhancers that specifically label parvalbumin neurons in the mouse and macaque.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Cohesin-dependence of neuronal gene expression relates to chromatin loop length

    Lesly Calderon, Felix D Weiss ... Matthias Merkenschlager
    Cohesin is required for the expression of neuronal genes that engage in long chromatin loops, while short-range enhancer-promoter loops can form in the absence of cohesin.
    1. Neuroscience

    Early detection of cerebrovascular pathology and protective antiviral immunity by MRI

    Li Liu, Steve Dodd ... Alan P Koretsky
    A MRI study of virally infected CNS demonstrates the utility of MRI in detecting the earliest pathological events and studying pathogen-specific T cells at the level of single cell as well as the therapeutic potential of antiviral T cells.