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Drugs are identified that unmask molecular origins of certain neuronal potassium currents, enabling functional analysis of previously indistinguishable potassium channel subtypes.

Commissureless works with the Nedd4 E3 ubiquitin ligase to transiently degrade the Robo1 receptor to allow commissural axons to cross the midline.

Greater differentiation of brain networks is a hallmark of good cognitive functioning among individuals who have avoided neurodegenerative disease and live longer than a typical human lifespan.

Subcortical brain structures contain neurons encoding subjective reports of stimulus detection in human participants, suggesting a role for conscious perception.

The characteristic hexagonal firing pattern of grid cells emerges as the most parsimonious solution to a trajectory code by cell sequences.

For the first time, mouse models reveal the metabolic dependency of photoreceptors on glutamine catabolism in vivo and further demonstrate the flexibility of photoreceptors to utilize fuel sources beyond glucose.

The breakdown of glutamine is an important metabolic pathway for the health and survival of rod photoreceptors within the retina.

ALP alterations in Q175 brains are late-onset, mild, existing at the later phases of the pathway, and stimulating autophagy at early disease progression enhances mHTT clearance to ameliorate HD pathology.