Browse our latest Stem Cells and Regenerative Medicine articles

Mammalian germ layer differentiation is characterized by transitions through discrete cell states, which are transcriptionally as well as functionally distinct.

Myomaker is activated on muscle stem cells to promote their fusion with myofibers, which is essential for induction of pro-growth signaling pathways and physiological muscle hypertrophy.

A new mechanism connects the loss of TGFβ signaling with invasion and metastasis in highly malignant transition zone tumors.

Anarchic, cycling piwi-1+ embryonic cells gives rise to neoblasts, pluripotent stemcells required for development of all organ systems during S. mediterranea embryogenesis, as well as the maintenance andregeneration of tissues during adulthood.

A genetically diverse panel of subject-specific induced pluripotent stem cells models the in vitro susceptibility of cardiac cells to develop a cardiotoxic drug response.

Personalized heart muscle cells made from stem cells in the laboratory could be used to check an individual’s response to potential new drugs before clinical trials.

Microtubule-depolymerizing kinesin, Klp10A, prevents overgrowth of the mother centrosome to prevent undesirable asymmetries during asymmetric divisions of Drosophila male germline stem cells.

A motor protein called Klp10A ensures that germline stem cells in male fruit flies divide to produce two sibling cells that are equal in size.

Building on previous work (Rodrigo Albors et al., 2015), we assess the contribution of individual cellular mechanisms in the context of spinal cord regeneration in the axolotl.

Ablation of canonical TGFβ signaling in muscle stem cells at any age is detrimental, and not beneficial, to effective skeletal muscle regeneration due to the promotion of premature fate commitment at the expense of progenitor amplification.