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The oligomerization domain of 53BP1, a key DNA repair protein, is a trimer which binds the dimeric hub protein LC8 by a novel mechanism to form dynamic heterogeneous complexes.

Restoring the Kv1-mediated pause in striatal cholinergic interneurons by reducing D5 receptor activity may help recover striatal function lost in dyskinetic parkinsonian mice.

The attentional blink selectively impairs one component of attention, and impacts both target detection and discrimination via separable neural signatures.

Dynamic shifts in neural coding combined with stable population subspaces enable visual areas to concurrently represent sensory inputs and working memory without mutual interference.

AlphaFold-guided in vitro and in vivo analyses establish the mechanism of ULK complex formation and provide a structural basis for understanding its role in mammalian autophagy initiation.

Self-supervised deep learning models can accurately perform 3D segmentation of cell nuclei in complex biological tissues, enabling scalable analysis in settings with limited or no ground truth annotations.

Activation of NMB/GRP receptors is not necessary for sigh generation, while SST preBötC neurons are critical for generation of sighs.

Group identification enhances collective performance through increased individual brain activation in the dorsolateral prefrontal cortex and neural synchronization in the orbitofrontal cortex, with connectivity between these regions linking individual and group decision-making processes.

The TRPV4 channel was identified as an obligatory regulator of physiological and pathological increases in intraocular pressure.