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Page 14 of 1,857
    1. Structural Biology and Molecular Biophysics

    A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution

    Saule Spokaite, Yohei Ohashi ... Roger L Williams
    Cryo-EM structures unexpectedly show that there are two binding sites for RAB5, with the VPS15 site being the most evolutionarily ancient site, which is essential for endocytic sorting.
    1. Neuroscience

    Computational mechanisms for temporal integration in the anterior claustrum

    Kuenbae Sohn, Donghyeon Yoon ... Sukwoo Choi
    Recurrent population dynamics in the anterior claustrum provide a candidate mechanism for integrating task-relevant signals across time.
    1. Microbiology and Infectious Disease

    LFA-1 interaction with GBP-130 on Plasmodium falciparum-infected red blood cells mediates NK cell activation and parasite control

    Osama Mukhtar, Ravi Dutt ... Pawan Malhotra
    Interaction between LFA-1 on natural killer cells and GBP-130 on infected erythrocytes enables immune recognition and killing of Plasmodium falciparum-infected red blood cells.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

    Elise J Meijer, Marissa Mueller ... Zoltán Molnár
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Evolutionary remodeling of non-canonical ORF translation in mammals

    Yue Chang, Tianyu Lei ... Hong Zhang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Analysis of dendritic input currents during place field dynamics

    Bence Fogel, Balázs B Ujfalussy
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology

    SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection

    Curdin A Franziscus, Alexia Ferrand ... Anne Spang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

    Chiara Asselborn, Agata N Makar ... Alexander von Kriegsheim
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Computational and Systems Biology

    High-frequency spike inference with particle Gibbs sampling

    Giovanni Diana, B Semihcan Sermet ... David A DiGregorio
    A Bayesian particle Gibbs framework enables unbiased spike time inference with millisecond resolution and jointly estimates uncertainties in both spike timing and model parameters from fast calcium imaging.
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