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Page 14 of 1,851
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins

    Bas de Boer, Thomas D Lamme ... Christopher T Schafer
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cancer Biology

    Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in lung adenocarcinoma

    Gaoming Liao, Xinbin Yang ... Gang Xu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons

    Sophie R Liebergall, Ethan M Goldberg
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Metabolic basis of the astrocyte-synapse interaction governs dopaminergic-motor connection

    Yanru Xu, Piaoping Kong ... Zhiguo Ma
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    Junctional and Actomyosin Dynamics Drive Endothelial Cell Rearrangements during Vascular Tube Formation

    Ludovico Maggi, Jianmin Yin ... Heinz-Georg Belting
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Stem Cells and Regenerative Medicine

    Endometrial epithelial cells with high ALDH activity control uterine development and regeneration

    Suni Tang, Anna Catherine Unser ... Diana Monsivais
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the recruitment of viral Type 2 IRES to ribosomal preinitiation complex for protein synthesis

    Deepakash Das, Tanweer Hussain
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    A single-cell transcriptomic atlas of inner ear morphogenesis in zebrafish

    Akankshi Munjal, Kalki Kukreja ... Ian A Swinburne
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Computational and Systems Biology

    Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability using UniDesign

    Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
    A fully computationally designed SaCas9 variant expands PAM recognition to NNNRRT, achieving up to 116-fold higher editing at noncanonical sites while matching the performance of experimentally evolved variants.
    1. Cancer Biology
    2. Cell Biology

    HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content

    Sara M Frangos, Henver S Brunetta ... Graham P Holloway
    Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
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