Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite
- The Sainsbury Laboratory, United Kingdom
- Max Planck Institute for Plant Breeding Research, Germany
- University of East Anglia, United Kingdom
- J.R. Simplot Company, United States
- University of Warwick, School of Life Sciences, United Kingdom
Abstract
How generalist parasites with wide host ranges can evolve is a central question in parasite evolution. Albugo candida is an obligate biotrophic parasite that consists of many physiological races that each specialize on distinct Brassicaceae host species. By analyzing genome sequence assemblies of five isolates, we show they represent three races that are genetically diverged by ~1%. Despite this divergence, their genomes are mosaic-like, with ~25% being introgressed from other races. Sequential infection experiments show that infection by adapted races enables subsequent infection of hosts by normally non-infecting races. This facilitates introgression and the exchange of effector repertoires, and may enable the evolution of novel races that can undergo clonal population expansion on new hosts. We discuss recent studies on hybridization in other eukaryotes such as yeast, Heliconius butterflies, Darwin's finches, sunflowers and cichlid fishes, and the implications of introgression for pathogen evolution in an agro-ecological environment.
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Author details
Reviewing Editor
- Detlef Weigel, Max Planck Institute for Developmental Biology, Germany
Publication history
- Received: September 1, 2014
- Accepted: February 26, 2015
- Accepted Manuscript published: February 27, 2015 (version 1)
- Version of Record published: April 2, 2015 (version 2)
Copyright
© 2015, McMullan et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite
eLife 4:e04550.
https://doi.org/10.7554/eLife.04550
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