(A) For the A-to-G sites, different tissues show varying levels of editing, globally, as well as site-specific tissue-dependent regulation. For example, higher modification levels (red) are observed in the GFL tissue whereas low levels (green) are observed in the VL tissue. Yet, some sites (top rows) are edited more strongly in VL. (B) Hierarchical clustering of the non A-to-G modification levels in the five different neuronal tissues. Consistently with the modifications being due to genomic polymorphisms, data cluster according to the animal it was taken from: modification levels in the GFL and OL tissues, which were taken from one individual animal, form one cluster, as do the VL, BG and SG tissues, taken from another individual animal. Modification levels are, by and large, uniform across tissues coming from the same individual animal. Note that in both panels only sites with significantly variable modification levels are presented (binomial analysis was performed with Bonferroni-corrected p-value of 0.05 as a cutoff), each row represents one modification site. Abbreviations: Giant fiber lobe (GFL), Optic lobe (OL), Vertical lobe (VL), Buccal ganglia (BG), and Stellate ganglion (SG).