1. Cell Biology
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COMP-1 promotes competitive advantage of nematode sperm

  1. Jody M Hansen
  2. Daniela R Chavez
  3. Gillian M Stanfield  Is a corresponding author
  1. University of Utah, United States
Research Article
  • Cited 12
  • Views 2,458
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Cite this article as: eLife 2015;4:e05423 doi: 10.7554/eLife.05423

Abstract

Competition among sperm to fertilize oocytes is a ubiquitous feature of sexual reproduction as well as a profoundly important aspect of sexual selection. However, little is known about the cellular mechanisms sperm use to gain competitive advantage or how these mechanisms are regulated genetically. Here, we utilize a forward genetic screen in C. elegans to identify a gene, comp-1, whose function is specifically required in competitive contexts. We show that comp-1 functions in sperm to modulate their migration through and localization within the reproductive tract, thereby promoting their access to oocytes. Contrary to previously-described models, comp-1 mutant sperm show no defects in size or velocity, thereby defining a novel pathway for preferential usage. Our results indicate not only that sperm functional traits can influence the outcome of sperm competition, but also that these traits can be modulated in a context-dependent manner depending on the presence of competing sperm.

Article and author information

Author details

  1. Jody M Hansen

    Department of Human Genetics, University of Utah, Salt Lake City, United States
    Competing interests
    The authors declare that no competing interests exist.
  2. Daniela R Chavez

    Department of Human Genetics, University of Utah, Salt Lake City, United States
    Competing interests
    The authors declare that no competing interests exist.
  3. Gillian M Stanfield

    Department of Human Genetics, University of Utah, Salt Lake City, United States
    For correspondence
    gillians@genetics.utah.edu
    Competing interests
    The authors declare that no competing interests exist.

Reviewing Editor

  1. Oliver Hobert, Columbia University, United States

Publication history

  1. Received: October 31, 2014
  2. Accepted: March 16, 2015
  3. Accepted Manuscript published: March 19, 2015 (version 1)
  4. Version of Record published: April 17, 2015 (version 2)

Copyright

© 2015, Hansen et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Further reading

Further reading

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