Network structure of brain atrophy in de novo Parkinson's Disease

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Cite this article as: eLife 2015;4:e08440 doi: 10.7554/eLife.08440

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Abstract

We mapped the distribution of atrophy in Parkinson's Disease (PD) using MRI and clinical data from 232 PD patients and 117 controls from the Parkinson's Progression Markers Initiative. Deformation based morphometry and independent component analysis identified PD-specific atrophy in the midbrain, basal ganglia, basal forebrain, medial temporal lobe, and discrete cortical regions. The degree of atrophy reflected clinical measures of disease severity. The spatial pattern of atrophy demonstrated overlap with intrinsic networks present in healthy brain, as derived from functional MRI. Moreover, the degree of atrophy in each brain region reflected its functional and anatomical proximity to a presumed disease epicenter in the substantia nigra, compatible with a trans-neuronal spread of the disease. These results support a network-spread mechanism in PD. Finally, the atrophy pattern in PD was also seen in healthy aging, where it also correlated with the loss of striatal dopaminergic innervation.

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Author details

Yashar Zeighami

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada

Competing interests
The authors declare that no competing interests exist.
Miguel Ulla

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada

Competing interests
The authors declare that no competing interests exist.
Yasser Iturria-Medina

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada

Competing interests
The authors declare that no competing interests exist.
Mahsa Dadar

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada

Competing interests
The authors declare that no competing interests exist.
Yu Zhang

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada

Competing interests
The authors declare that no competing interests exist.
Kevin Michel-Herve Larcher

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada

Competing interests
The authors declare that no competing interests exist.
Vladimir Fonov

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada

Competing interests
The authors declare that no competing interests exist.
Alan C Evans

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada

Competing interests
The authors declare that no competing interests exist.
Douglas Louis Collins

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada

Competing interests
The authors declare that no competing interests exist.
Alain Dagher

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada

For correspondence
alain.dagher@mcgill.ca

Competing interests
The authors declare that no competing interests exist.

Ethics

Human subjects: For the Parkinson's Progression Markers Initiative (PPMI) database (www.ppmi-info.org/data)Each participating PPMI site received approval from a local research ethics committee before study initiation, and obtained written informed consent from all subjects participating in the study.For the resting state fMRI data collected in our lab, We acquired resting state fMRI in 51 healthy, right-handed volunteers.The experimental protocol was reviewed and approved by Research Ethics Board of Montreal Neurological Institute. All subjects gave informed consent.

Reviewing Editor

David C Van Essen, Washington University in St Louis, United States

Publication history

Received: April 30, 2015
Accepted: September 5, 2015
Accepted Manuscript published: September 7, 2015 (version 1)
Version of Record published: October 8, 2015 (version 2)

Copyright

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.