Competing basal ganglia pathways determine the difference between stopping and deciding not to go

  1. Kyle Dunovan
  2. Brighid Lynch
  3. Tara Molesworth
  4. Timothy Verstynen  Is a corresponding author
  1. University of Pittsburgh, United States
  2. University of Pittsburgh and Carnegie Mellon University, United States
  3. Carnegie Mellon University, United States
8 figures, 2 tables and 1 additional file

Figures

Conceptual framework of stopping and deciding not to go as separate but dependent processes.

(A) The organization of corticobasal ganglia pathways. Execution signals are relayed via the direct pathway (green connections) that result in a disinhibition of thalamic signals to cortex form the …

https://doi.org/10.7554/eLife.08723.003
Reactive stopping task and behavioral results.

(A) Timeline of a go (left) and stop trial (right) in the reactive experiment. (B) Mean observed probability of stopping in the baseline (dark, solid) and caution (light, dotted) conditions; dots …

https://doi.org/10.7554/eLife.08723.004
Comparison of reactive stopping models.

Fits of the three reactive models (Figure 1C–E) to behavioral data in the baseline condition, shown against (A) the histogram of RTs for correct (top) and incorrect (i.e., responses made on stop …

https://doi.org/10.7554/eLife.08723.005
Figure 4 with 1 supplement
Comparison of modulation models in reactive task.

Goodness-of-fit measures for execution modulation models in reactive task. Bars show the estimated Akaike information criterion (AIC) and Bayesian information criterion (BIC) for the drift, onset, …

https://doi.org/10.7554/eLife.08723.007
Figure 4—figure supplement 1
Model predictions of behavior in reactive task.

Example fits for modulation models on the execution process inthe baseline and caution conditions of the reactive task. Predicted RT distributions and stop accuracy are shown for the (A) drift-rate …

https://doi.org/10.7554/eLife.08723.008
Figure 5 with 1 supplement
Proactive no-go decision task and behavioral results.

(A) Timeline of correct high (left) and low (right) go probability trials in the proactive task. The low probability example shows a trial in which a stop signal was presented. (B) Mean probability …

https://doi.org/10.7554/eLife.08723.009
Figure 5—figure supplement 1
Subject-wise correlation of reactive and proactive control.

Correlation between the average PSEs in the reactive stopping curves and proactive no-go curves collapsed across baseline and caution conditions. Each point represents a single subject. PSE: point …

https://doi.org/10.7554/eLife.08723.010
Figure 6 with 1 supplement
Comparison of modulation models in proactive task.

Goodness-of-fit measures for execution process modulation models in proactive task. Same plotting conventions as in Figure 4. As with the reactive experiment, the drift modulation model provided …

https://doi.org/10.7554/eLife.08723.011
Figure 6—figure supplement 1
Model predictions of behavior in proactive task.

Predicted RT distributions and no-go probability curves in the proactive task for the drift modulation (green, A), onset modulation (blue, B), onset and drift modulation (yellow, C), and boundary …

https://doi.org/10.7554/eLife.08723.012
Simulated interaction between trial outcome and response expectation on BOLD activation.

Time-course of BOLD and mean activity in the proactive task predicted by the (A) drift modulation, (B) onset modulation, and (C) boundary modulation models. Time courses (left column) reflect the …

https://doi.org/10.7554/eLife.08723.014
Figure 8 with 1 supplement
Observed interaction between trial outcome and response expectation on BOLD activation.

Contrast maps for the comparison of no-go responses, modulated by go trial probability, against modulated go responses in the proactive task (center panel). Warm colors show areas where the …

https://doi.org/10.7554/eLife.08723.015
Figure 8—figure supplement 1
In-scanner EMG protocol.

(A) Example of modified EMG set-up using the in-house Siemens physiological monitoring unit for monitoring cardiac signals. The recording sensors were placed to estimate the electrical vector from …

https://doi.org/10.7554/eLife.08723.016

Tables

Table 1

Reactive model parameter estimates and fit statistics. In the top panel, best fit parameter estimates for boundary height (a), onset delay (tr), execution drift rate (ve), braking drift rate (vb), …

https://doi.org/10.7554/eLife.08723.006
Modela tr ve vb sso xb χ2AICBIC
DPM0.5340.1741.266−0.9900.8780.0028−122.40−128.018
Ind-RM0.2500.3381.1271.2691.520.0075−106.652−112.270
Int-RM0.4450.2201.1953.0230.1971.4740.0069−104.379−111.815
Drift0.5360.178B: 1.289
C: 1.243
−0.9840.8770.0051−273.459−273.301
Onset0.531B:0.171
C: 0.180
1.236−0.9600.8930.0054−271.651−271.492
Drift and
onset
0.538B: 0.173
C: 0.178
B: 1.269
C: 1.247
−0.9890.8580.0063−260.793−263.941
BoundB: 0.525
C: 0.551
0.1781.268-0.9840.8780.0057−269.994−269.835
  1. DPM: dependent process model; Ind-RM: independent race model; Int-RM: interactive race model.

Table 2

Proactive model parameter estimates and fit statistics. Best fit parameter estimates for boundary height (a), onset delay (tr), execution drift rate (ve), and dynamic bias gain (xb) are listed for …

https://doi.org/10.7554/eLife.08723.013
Modela tr ve xb P0P20P40P60P80P100cXχ2AICBIC
Drift0.4870.2921.563ve 1.4111.5621.6831.7611.8801.9250.0022−122.65−130.08
Onset0.6281.420.641tr 0.1820.1610.1340.1170.0840.0760.0095−99.38−106.81
Drift and onset0.061.468ve 0.8310.9700.9680.9790.9321.0790.0033−104.65−122.77
tr 0.5150.5060.4920.4790.4510.463
Bound0.2720.9140.913a 0.3790.3440.3050.2810.2460.2360.0099−98.65−106.09

Additional files

Supplementary file 1

Table of significant clusters for the no-go parametric minus go parametric contrast shown in Figure 8A.

Coordinates are centers of mass for the cluster in MNI-space. N is the number of voxels in each cluster. Values in the left six columns show average condition-wise (general linear model) GLM coefficients and standard deviation across subjects is in parentheses.

https://doi.org/10.7554/eLife.08723.017

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