(A,B) Body weight (A) and plasma glucose levels (B) of Ppara+/+ and Ppara-/- pups at the indicated postnatal days. (C) Alanine aminotransferase (ALT) activity measured in liver lysates at P2. (D) Gluconeogenesis pathway in Ppara-/- liver at P2 with the supply of pyruvate through the anaplerotic metabolism of alanine indicated. (E) The affected amino acid oxidation pathways in Ppara-/- liver at P2. Colors indicate up-regulation (red) or down-regulation (blue) of genes identified by microarray analysis. The up-regulated genes are Hal (1), Uroc1(2), Amdhd1 (3), Ftcd (4), Glud (5), Pycr (6), Oat (7), Fah (8), Asl (9), Ass1 (10), Got2 (11), Got1 (12), Sds (13), Cth (14), Cbs (15), Cdo1 (16), Got1 (17), Sds (18), Gpt (19), Pcx (20). The down-regulated genes are Ehhadh (21,22,24), Hibch (23), Hmgcs2 (25), Hmgcl (26). (F,G) Body weight (F) and blood glucose (G) of P2pups before and after daily intraperitoneal injections of 30 mg/kg L-cycloserine for two days (P4), three days (P5), and four days (P6). Bars represent means ± SEM; n = 4–6, *p<0.05, **p<0.01 vs. wild-type controls (two-way Mann-Whitney test).