Dbx1 precursor cells are a source of inspiratory XII premotoneurons
- University of Alberta, Canada
- The College of William and Mary, United States
- Washington University School of Medicine, United States
Figures
Figure 1
Fifty-seven percent of Dbx1 IRt neurons are glutamatergic.
(A) Composite diagram of a neonatal mouse medullary slice showing (left) a schematic of the multi-synaptic medullary circuit where inspiratory rhythm in vitro is generated within the preBötC (red), …
Figure 2
Inspiratory Dbx1 IRt neurons are ipsilaterally projecting, putative XII premotoneurons.
(A) Right half of the rhythmic slice preparation after PFA fixation and optical clearing using the Scale method. White arrow points to the soma of the inspiratory-modulated Dbx1 neuron, which is …
Figure 3
Electrophysiological characteristics of Dbx1 IRt neurons.
(A) Membrane potential recording (Vm) from an inspiratory Dbx1 IRt neuron and integrated XII nerve (∫XII) activity showing inspiratory burst characteristics. Inspiratory drive amplitude for neurons …
Figure 4
Dbx1 IRt neurons contribute significantly to XII inspiratory burst output.
(A) Confocal image of a rhythmic slice preparation after fixation and Scale clearing illustrating the region targeted for laser ablations within the white rectangle on the right-hand side. Bilateral …
