1. Structural Biology and Molecular Biophysics
  2. Cell Biology
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Ion Channels: Signaling the differences between cilia

  1. Polina Lishko  Is a corresponding author
  2. Yuriy Kirichok  Is a corresponding author
  1. University of California, Berkeley, United States
  2. University of California, San Francisco, United States
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Cite this article as: eLife 2015;4:e12760 doi: 10.7554/eLife.12760
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The diversity of cilia.

There are two types of cilia, primary cilia and undulipodia, which are distinguished by differences in the structure of their axoneme. The level of calcium ions (Ca2+) inside the cilia is regulated by specialized ion channels. (A) The main Ca2+ channel for primary cilia has been identified as the PKD1L1/PKD2L1 complex. (B) There are two types of undulipodia: motile cilia and flagella. The main Ca2+ channel of mammalian flagella was identified as a protein called CatSper in 2013. Doerner et al. have now identified an L-type voltage-gated Ca2+ channel (Cav1 family) as the main Ca2+ channel for motile cilia.

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