DYT1 dystonia increases risk taking in humans

Abstract
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Abstract

It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a single-mutation motor disorder, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymmetric learning predicts risk taking in probabilistic tasks. Here we demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans.

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David Arkadir

Department of Neurology, Hadassah Medical Center, Hadassah Medical Center and the Hebrew University, Jerusalem, Israel

Competing interests
The authors declare that no competing interests exist.
Angela Radulescu

Psychology Department, Princeton Neuroscience Institute, Princeton University, Princeton, United States

Competing interests
The authors declare that no competing interests exist.
Deborah Raymond

Department of Neurology, Beth Israel Medical Center, New York, United States

Competing interests
The authors declare that no competing interests exist.
Naomi Lunar

Department of Neurology, Beth Israel Medical Center, New York, United States

Competing interests
The authors declare that no competing interests exist.
Susan B Bressman

Department of Neurology, Beth Israel Medical Center, New York, United States

Competing interests
The authors declare that no competing interests exist.
Pietro Mazzoni

The Neurological Institute, Columbia University, New York, United States

Competing interests
The authors declare that no competing interests exist.
Yael Niv

Psychology Department, Princeton Neuroscience Institute, Princeton University, Princeton, United States

For correspondence
yael@princeton.edu

Competing interests
The authors declare that no competing interests exist.

Ethics

Human subjects: All participants gave informed consent and the study was approved by the Institutional Review Boards of Columbia University, Beth Israel Medical Center, and Princeton University.

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This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.