It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a single-mutation motor disorder, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymmetric learning predicts risk taking in probabilistic tasks. Here we demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans.
Human subjects: All participants gave informed consent and the study was approved by the Institutional Review Boards of Columbia University, Beth Israel Medical Center, and Princeton University.
- Rui M Costa, Fundação Champalimaud, Portugal
© 2016, Arkadir et al.
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