Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'
- Collège de France, France
- The Francis Crick Institute, United Kingdom
- University College London, United Kingdom
- Massachusetts Institute of Technology, United States
- Duke University, United States
Abstract
Perturbations in neural circuits can provide mechanistic understanding of the neural correlates of behavior. In M71 transgenic mice with a 'monoclonal nose', glomerular input patterns in the olfactory bulb are massively perturbed and olfactory behaviors are altered. To gain insights into how olfactory circuits can process such degraded inputs we characterized odor-evoked responses of olfactory bulb mitral cells and interneurons. Surprisingly, calcium imaging experiments reveal that mitral cell responses in M71 transgenic mice are largely normal, highlighting a remarkable capacity of olfactory circuits to normalize sensory input. In vivo whole cell recordings suggest that feedforward inhibition from olfactory bulb periglomerular cells can mediate this signal normalization. Together, our results identify inhibitory circuits in the olfactory bulb as a mechanistic basis for many of the behavioral phenotypes of mice with a 'monoclonal nose' and highlight how substantially degraded odor input can be transformed to yield meaningful olfactory bulb output.
Article and author information
Author details
Reviewing Editor
- Upinder S Bhalla, National Centre for Biological Sciences, India
Ethics
Animal experimentation: All experiments were performed in accordance with approved institutional animal care and use committee protocols of Columbia University (#AC-AAAH9255), and in accordance with the INSERM Animal Care and Use Committee guidelines (#B750512/00615.02), the German Animal Welfare Act, and the UK Home Office and the Animals and Scientific Procedures Act (#PPL 70/7827).
Version history
- Received: March 23, 2016
- Accepted: May 12, 2016
- Accepted Manuscript published: May 13, 2016 (version 1)
- Version of Record published: June 23, 2016 (version 2)
- Version of Record updated: June 29, 2016 (version 3)
Copyright
© 2016, Roland et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'
eLife 5:e16335.
https://doi.org/10.7554/eLife.16335
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