Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models

  1. Hui Qin Wang
  2. Ensar Halilovic
  3. Xiaoyan Li
  4. Jinsheng Liang
  5. Yichen Cao
  6. Daniel P Rakiec
  7. David A Ruddy
  8. Sebastien Jeay
  9. Jens U Wuerthner
  10. Noelito Timple
  11. Shailaja Kasibhatla
  12. Nanxin Li
  13. Juliet A Williams
  14. William R Sellers
  15. Alan Huang
  16. Fang Li  Is a corresponding author
  1. Novartis Institutes for BioMedical Research, United States
  2. Novartis Institutes for BioMedical Research, Switzerland
  3. Genomics Institute of the Novartis Research Foundation, United States
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  1. Hui Qin Wang
  2. Ensar Halilovic
  3. Xiaoyan Li
  4. Jinsheng Liang
  5. Yichen Cao
  6. Daniel P Rakiec
  7. David A Ruddy
  8. Sebastien Jeay
  9. Jens U Wuerthner
  10. Noelito Timple
  11. Shailaja Kasibhatla
  12. Nanxin Li
  13. Juliet A Williams
  14. William R Sellers
  15. Alan Huang
  16. Fang Li
(2017)
Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models
eLife 6:e17137.
https://doi.org/10.7554/eLife.17137