Maximally diverged LAP1 and LULL1 sequences are aligned. If not experimentally confirmed, sequences were assigned as LAP1 or LULL1 based on the presence of an N-terminal, extraluminal domain with basic signature, characteristic of LAP1. Secondary structure elements of human LULL1 are displayed above the alignment. The strictly conserved Arg-finger is boxed. TorsinA contacts, red circles, conserved cysteines, yellow circles. Disulfide bridge depicted as a yellow line. hs, Homo sapiens; oa, Ornithorhynchus anatinus; gg, Gallus gallus; tr, Takifugu rubripes; dr, Danio rerio; nv, Nematostella vectensis; bf, Branchiostoma floridae; stp, Strongylocentrotus purpuratus; ci, Ciona intestinalis; ce, Caenorhabditis elegans; dm, Drosophila melanogaster; ta, Trichoplax adherens.