1. Cancer Biology
  2. Cell Biology
Download icon

Mathematical Modeling: Tuning the MYC response

  1. Ying Zheng
  2. David Levens  Is a corresponding author
  1. National Cancer Institute, United States
Insight
Cite this article as: eLife 2016;5:e18871 doi: 10.7554/eLife.18871
1 figure

Figures

The ability of MYC to bind to individual promoters is influenced by interactions with DNA and other proteins.

The MYC protein forms a dimer with another protein called MAX, which allows it to bind to virtually any promoter in the genome and increase gene expression by activating transcription (green arrow). However, the ability of MYC to bind to individual promoters (binding affinity) varies. MYC prefers to bind to DNA motifs called E-boxes, but will also bind to other DNA sequences with lower affinity. A protein called WDR5, which is associated with the DNA of active genes, can help to recruit MYC to particular promoters (beige arrow). MYC also interacts with other DNA-associated proteins – including TRAPP, Paf1, BRD4 and PTEF-b – during transcription, which may also help MYC to bind to certain promoters with higher affinity.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)