The MYC protein forms a dimer with another protein called MAX, which allows it to bind to virtually any promoter in the genome and increase gene expression by activating transcription (green arrow). However, the ability of MYC to bind to individual promoters (binding affinity) varies. MYC prefers to bind to DNA motifs called E-boxes, but will also bind to other DNA sequences with lower affinity. A protein called WDR5, which is associated with the DNA of active genes, can help to recruit MYC to particular promoters (beige arrow). MYC also interacts with other DNA-associated proteins – including TRAPP, Paf1, BRD4 and PTEF-b – during transcription, which may also help MYC to bind to certain promoters with higher affinity.