(A,B) Analysis of gene expression changes induced by KCl/FPL in Hum-ESCCORT-neurons (A) and DIV10 Mus-PRIMCORT-neurons (B). Normalised RNA-seq read density (FPKM) mapping to each gene in RNA …
Data set relating to Figure 1a–e.
Data set relating to Figure 1—figure supplement 1a.
Data set relating to Figure 1—figure supplement 1b.
Data set relating to Figure 1—figure supplement 1c–d.
Data set relating to Figure 1—figure supplement 1e–f.
(A) Example fluo-3 Ca2+ imaging trace of KCL/FPL-treated Hum-ESCCORT-neurons. (B) qPCR analysis of the fold induction of the indicated genes in Hum-ESCCORT-neurons after 4h of KCl/FPL treatment. …
(A) Example immunofluorescence pictures of Mus-ESCCORT-neurons stained for neuronal markers Tuj1 (upper) and Reelin (lower). Note also absence of Nestin staining (upper), a marker of …
Data set relating to Figure 2e–g.
Data set relating to Figure 2—figure supplement 1e.
Data set relating to Figure 2—figure supplement 1b–d.
(A) Normalised RNA-seq read density (FPKM) mapping to each gene in RNA extracted from control vs. KCl/FPL-treated Mus-ESCCORT-neurons is shown (n = 3 independent biological replicates). Genes whose …
(A) Analysis of gene expression changes induced by KCl/FPL in mouse Tc1 neurons. Mouse genes are shown in grey, human chromosome-21 (Hsa-21) genes in red. (B) The graph concerns 72 orthologous pairs …
Data set relating to Figure 3—figure supplement 1a.
Data set relating to Figure 3b.
Data set relating to Figure 3c–f.
(A) Correlation of KCl/FPL-induced fold-change in the same 11,302 mouse genes analysed in Figures 1 and 2,in DIV10 Mus-ESCCORT-neurons from wild-type vs. Tc1 primary cortical neurons, showing the …