Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks
- Medical Research Council Brain Network Dynamics Unit at the University of Oxford, United Kingdom
- John Radcliffe Hospital, University of Oxford, United Kingdom
- King’s College Hospital, United Kingdom
- University College London Institute of Neurology, United Kingdom
Figures
Figure 1 with 1 supplement
Paradigm and behavioral data.
(A–C) Overview of experimental task and the 2*2 study design. (D) Histograms of RT distributions for correct (blue) and error (red) trials for all four conditions. (E) Second level comparison of …
Figure 1—figure supplement 1
Behavioral data of healthy participants.
(A) Histograms of RT distributions for correct (blue) and error (red) trials for all four conditions. (B) Group-averaged reaction times and accuracy rates. HC, high coherence; LC, low coherence. …
Figure 2 with 1 supplement
Drift diffusion modeling.
(A) Schematic illustration of DDM. t is the non-decision time, v the drift rate and a the decision threshold. The upper boundary in the upper row indicates the threshold for the correct response, …
Figure 2—figure supplement 1
Drift diffusion modeling in healthy participants.
(A) Quantile probability plots showing the observed (x) and predicted (ellipses) RT against their cumulative probabilities (10, 30, 50, 70 and 90 percentiles). The widths of the ellipses represent …
Figure 3 with 2 supplements
Response-aligned STN power changes.
(A) Time frequency spectrum aligned to the onset of the motor response from −1.5 to +1.5 s averaged across conditions. (B) Spectra shown separately for the four conditions. The color map is …
Figure 3—figure supplement 1
STN channel selection.
Example of channel selection for one representative patient (patient #6). Response-aligned time frequency spectra are shown for the three bipolar channels (from left to right: ventral -> middle -> …
Figure 3—figure supplement 2
Differences in STN power between correct and incorrect trials.
Response-aligned time frequency spectra are shown in the left column, while spectra aligned to the onset of the moving dots are shown in the right column for correct (upper row) and incorrect (lower …
Figure 4
STN power changes aligned to the onset of the moving dots.
(A) Time frequency spectrum aligned to the onset of the cue from −0.5 to +1.5 s averaged across conditions. (B) Spectra shown separately for the four conditions. The color map is identical to A. (C) …
Figure 5
STN power changes predict adjustments of decision thresholds.
(A) Histograms of the z-scored single trial values of the increase in LFO before the response (−750 ms before the response until the response) and cue-induced decrease in beta power (150 ms to 400 …
Figure 6
Task-related changes in cortical activity and cortico-STN connectivity.
(A) Time frequency spectrum for EEG at electrode Fz aligned to the motor response (from −1.5 to +1.5 s) and cue-onset (from −0.5 to 1.5 s) averaged across conditions. The pre-response increase in …
Additional files
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Supplementary file 1
Clinical specifications.
Age and disease duration are given in years. UPDRS-III: Unified Parkinson’s disease rating scale part III.
- https://doi.org/10.7554/eLife.21481.013
