(A) Surface representation of the apo pdP2X7 receptor viewed from the side. Light blue, yellow, and light pink represent each subunit. Green residues are the A804598 binding residues (F88, F95, F103, M105, F108 and Y295). Light pink subunit is presented as semi-transparent surface for visualizing the yellow and blue subunits. (B) Zoomed in drug-binding pocket of the pdP2X7 shown in (A). (C) CPK sphere representation of A804598 at the same magnification and orientation as the drug binding site shown in (B). (D) Equivalent pocket in apo zfP2X4. The green residues represent counterparts of the A804598 binding residues (W87, I94, F103, L105, M108, and F289).