Nonlinear feedback drives homeostatic plasticity in H2O2 stress response
- Institut de Génétique et de Biologie Moléculaire et Cellulaire, France
- IBITECS, SBIGEM, CEA-Saclay, France
- University of Gothenburg, Sweden
Abstract
Homeostatic systems that rely on genetic regulatory networks are intrinsically limited by the transcriptional response time, which may restrict a cell's ability to adapt to unanticipated environmental challenges. To bypass this limitation, cells have evolved mechanisms whereby exposure to mild stress increases their resistance to subsequent threats. However, the mechanisms responsible for such adaptive homeostasis remain largely unknown. Here, we used live-cell imaging and microfluidics to investigate the adaptive response of budding yeast to temporally controlled H2O2 stress patterns. We demonstrate that acquisition of tolerance is a systems-level property resulting from nonlinearity of H2O2 scavenging by peroxiredoxins and our study reveals that this regulatory scheme induces a striking hormetic effect of extracellular H2O2 stress on replicative longevity. Our study thus provides a novel quantitative framework bridging the molecular architecture of a cellular homeostatic system to the emergence of nonintuitive adaptive properties.
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Author details
Funding
Association de recherche contre le cancer (PDF20111204470)
- Youlian Goulev
ATIP-Avenir program
- Gilles Charvin
Fondation pour la Recherche Médicale (DEI20151234397)
- Gilles Charvin
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Copyright
© 2017, Goulev et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Nonlinear feedback drives homeostatic plasticity in H2O2 stress response
eLife 6:e23971.
https://doi.org/10.7554/eLife.23971
